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• W2078173802 abstract "Annals of the New York Academy of SciencesVolume 665, Issue 1 p. 72-80 Perfusion Cultures of Hybridoma Cells for Monoclonal Antibody Production FRANCISCO J. CASTILLO, FRANCISCO J. CASTILLO XOMA Corporation, Berkeley, California 94710Search for more papers by this authorLARRY J. MULLEN, LARRY J. MULLEN XOMA Corporation, Berkeley, California 94710Search for more papers by this authorJOHN C. THRIFT, JOHN C. THRIFT XOMA Corporation, Berkeley, California 94710Search for more papers by this authorBARRY C. GRANT, BARRY C. GRANT XOMA Corporation, Berkeley, California 94710Search for more papers by this author FRANCISCO J. CASTILLO, FRANCISCO J. CASTILLO XOMA Corporation, Berkeley, California 94710Search for more papers by this authorLARRY J. MULLEN, LARRY J. MULLEN XOMA Corporation, Berkeley, California 94710Search for more papers by this authorJOHN C. THRIFT, JOHN C. THRIFT XOMA Corporation, Berkeley, California 94710Search for more papers by this authorBARRY C. GRANT, BARRY C. GRANT XOMA Corporation, Berkeley, California 94710Search for more papers by this author First published: October 1992 https://doi.org/10.1111/j.1749-6632.1992.tb42575.xCitations: 4AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Kruse, P. F. 1972. Use of perfusion systems for growth of cell and tissue culture. In Growth, Nutrition, and Metabolism of Cells in Culture. Vol. 2. G. Rothblat & V. Cristofalo, Eds.: 11–66. Academic Press. New York . 2 Merten, O. W. 1987. Concentrating mammalian cells. I. Large-scale animal cell culture. Trends Biotechnol. 5: 230–237. 3 Tharakan, J. P., S. L. Gallaher & P. C. Chau. 1988. Hollow-fiber bioreactors for mammalian cell culture. In Upstream Processes: Equipment and Techniques. Advances in Biotechnological Processes. Vol. 7. A. Mizrahi, Ed.: 153–184. Alan R. Liss. New York . 4 Tyo, M. A., B. J. Bulbulian, B. Z. Menken & T. J. Murphy. 1988. Large-scale cell culture utilizing Acusyst technology. In Animal Cell Biotechnology. Vol. 3. R. Spier & J. Griffiths, Eds.: 357–371. Academic Press. New York . 5 Knight, P. 1989. Hollow fiber bioreactors for mammalian cell culture. Bio/Technology 7: 459–461. 6 Piret, J. M. & C. L. Cooney. 1990. Immobilized mammalian cell cultivation in hollow fiber bioreactors. Biotechnol. Adv. 8: 763–783. 7 Von Wedel, R. J. 1987. Mass culture of mouse and human hybridoma cells in hollow-fiber culture. In Commercial Production of Monoclonal Antibodies: A Guide for Scale-up. S. Seaver, Ed.: 159–173. Dekker. New York . 8 Andersen, B. G. & M. L. Gruenberg. 1987. Optimization techniques for the production of monoclonal antibodies utilizing hollow-fiber technology. In Commercial Production of Monoclonal Antibodies: A Guide for Scale-up. S. Seaver, Ed.: 175–195. Dekker. New York . 9 Reuveny, S. & A. Lazar. 1989. Equipment and procedures for production of monoclonal antibodies in culture. In Monoclonal Antibodies: Production and Applications. Advances in Biotechnological Processes. Vol. 11. A. Mizrahi, Ed.: 45–80. Alan R. Liss. New York . 10 Murakami, H., H. Masui, G. H. Sato, N. Sueoka, T. P. Chow & T. Kano-Sueoka. 1982. Growth of hybridoma cells in serum-free medium: ethanolamine is an essential component. Proc. Natl. Acad. Sci. U.S.A. 79: 1158–1162. 11 Pye, I. F., C. Stonier & H. F. McGale. 1978. Double-enzymatic assay for determination of glutamine and glutamic acid in cerebrospinal fluid and plasma. Anal. Chem. 50: 951–953. 12 Burke, D., J. Duncan, C. Siebert & B. Ott. 1986. Rapid cation-exchange chromatography of hemoglobins and other proteins. J. Chromatogr. 359: 533–540. 13 Miller, W. M. 1987. A kinetic analysis of hybridoma growth and metabolism. Ph.D. dissertation. University of California, Berkeley. 14 Custer, L. M. 1988. Physiological studies of hybridoma cultivation in hollow fiber bioreactors. Ph.D. dissertation. University of California, Berkeley. 15 Miller, W. M., H. W. Blanch & C. R. Wilke. 1988. A kinetic analysis of hybridoma growth and metabolism in batch and continuous culture: effect of nutrient concentration, dilution rate, and pH. Biotechnol. Bioeng. 32: 947–965. 16 Pirt, S. J. 1975. Principles of Microbe and Cell Cultivation. Blackwell. Oxford . 17 Castillo, F. J., J. Thrift, T. Bruggman, L. Mullen & W. C. McGregor. 1987. Growth and monoclonal antibody production by several hybridomas in continuous culture. Presented at the 194th National Meeting ACS, New Orleans. 18 Castillo, F. J., J. Thrift, L. Mullen, G. Bostic & W. C. McGregor. 1988. Growth and monoclonal antibody production by murine hybridomas in serum-free medium. Presented at the 196th National Meeting ACS, Los Angeles. 19 Merten, O. W., G. Palfi, G. Klement & F. Steindl. 1987. Specific kinetic patterns of production of monoclonal antibodies in batch cultures and consequences on fermentation processes. In Modern Approaches to Animal Cell Technology. R. E. Spier & J. B. Griffiths, Eds.: 381. Butterworths. London . 20 Merten, O. W. 1988. Batch production and growth kinetics of hybridomas. Cytotechnology 1: 113–121. 21 Harbour, C., J. P. Barford & K. S. Low. 1988. Process development for hybridoma cells. Adv. Biochem. Eng./Biotechnol. 37: 1–40. 22 Mancuso, A., E. J. Fernandez, H. W. Blanch & D. S. Clark. 1990. A nuclear magnetic resonance technique for determining hybridoma cell concentration in hollow fiber bioreactors. Bio/Technology 8: 1282–1285. 23 Ehrlich, K., E. Steward & E. Klein. 1978. Artificial capillary perfusion cell culture: metabolic studies. In Vitro 14: 443–450. 24 Chresand, T. J., R. J. Gillies & B. E. Dale. 1988. Optimum fiber spacing in a hollow fiber bioreactor. Biotechnol. Bioeng. 32: 983–992. 25 Blute, T., R. J. Gillies & B. E. Dale. 1988. Cell density measurements in hollow fiber bioreactors. Biotechnol. Prog. 4: 202–209. 26 Kidwell, W. R. 1989. Filtering out inhibition. Bio/Technology 7: 462–463. 27 Seaver, S. 1987. Culture method affects antibody secretion of hybridoma cells. In Commercial Production of Monoclonal Antibodies: A Guide for Scale-up. S. Seaver, Ed.: 49–71. Dekker. New York . 28 Lee, G. M. & B. O. Palsson. 1990. Immobilization can improve the stability of hybridoma antibody productivity in serum-free media. Biotechnol. Bioeng. 36: 1049–1055. 29 Spalding, B. J. 1991. A growth market for bioreactors. Bio/Technology 9: 338–341. Citing Literature Volume665, Issue1Biochemical Engineering VII: Cellular and Reactor EngineeringOctober 1992Pages 72-80 ReferencesRelatedInformation" @default.
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