Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078174663> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2078174663 endingPage "49" @default.
- W2078174663 startingPage "44" @default.
- W2078174663 abstract "We performed experiments to determine the effects of ionizing radiation exposure on expression of genes such as beta-actin, c-fos, histone H4, c-myc, c-jun, Rb, and p53 after exposure of Syrian hamster embryo (SHE) cells to the protein synthesis inhibitor cycloheximide. The purpose of these experiments was to determine the role of a labile protein in the radiation-induced response. The results revealed that when ionizing radiation (either fission-spectrum neutrons or gamma rays) was administered 15 min after cycloheximide treatment of SHE cells, the radiation exposure reduced cycloheximide-mediated gene induction of c-fos, histone H4, and c-jun. In addition, dose-rate differences were found when radiation exposure most significantly inhibited the cycloheximide response. Our results suggest that ionizing radiation does not act as a general protein-synthesis inhibitor and that the presence of a labile protein is required for the maintenance of specific gene transcription and mRNA accumulation after radiation exposure, especially at high dose-rates." @default.
- W2078174663 created "2016-06-24" @default.
- W2078174663 creator A5008883531 @default.
- W2078174663 creator A5046002828 @default.
- W2078174663 creator A5088225290 @default.
- W2078174663 date "1995-05-01" @default.
- W2078174663 modified "2023-09-26" @default.
- W2078174663 title "Combined effects of ionizing radiation and cycloheximide on gene expression" @default.
- W2078174663 cites W1861749169 @default.
- W2078174663 cites W1967116429 @default.
- W2078174663 cites W2018007773 @default.
- W2078174663 cites W2019094219 @default.
- W2078174663 cites W2021253208 @default.
- W2078174663 cites W2023246619 @default.
- W2078174663 cites W2039572198 @default.
- W2078174663 cites W2045854456 @default.
- W2078174663 cites W2048180296 @default.
- W2078174663 cites W2064863660 @default.
- W2078174663 cites W2068474260 @default.
- W2078174663 cites W2080165053 @default.
- W2078174663 cites W2132000251 @default.
- W2078174663 cites W2140798038 @default.
- W2078174663 cites W2141618181 @default.
- W2078174663 doi "https://doi.org/10.1002/mc.2940130108" @default.
- W2078174663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7539271" @default.
- W2078174663 hasPublicationYear "1995" @default.
- W2078174663 type Work @default.
- W2078174663 sameAs 2078174663 @default.
- W2078174663 citedByCount "12" @default.
- W2078174663 countsByYear W20781746632018 @default.
- W2078174663 crossrefType "journal-article" @default.
- W2078174663 hasAuthorship W2078174663A5008883531 @default.
- W2078174663 hasAuthorship W2078174663A5046002828 @default.
- W2078174663 hasAuthorship W2078174663A5088225290 @default.
- W2078174663 hasBestOaLocation W20781746632 @default.
- W2078174663 hasConcept C104317684 @default.
- W2078174663 hasConcept C111337013 @default.
- W2078174663 hasConcept C121332964 @default.
- W2078174663 hasConcept C138885662 @default.
- W2078174663 hasConcept C150194340 @default.
- W2078174663 hasConcept C153911025 @default.
- W2078174663 hasConcept C179926584 @default.
- W2078174663 hasConcept C18231593 @default.
- W2078174663 hasConcept C185544564 @default.
- W2078174663 hasConcept C2778128677 @default.
- W2078174663 hasConcept C2778575167 @default.
- W2078174663 hasConcept C29512474 @default.
- W2078174663 hasConcept C3675279 @default.
- W2078174663 hasConcept C41895202 @default.
- W2078174663 hasConcept C54355233 @default.
- W2078174663 hasConcept C86339819 @default.
- W2078174663 hasConcept C86803240 @default.
- W2078174663 hasConceptScore W2078174663C104317684 @default.
- W2078174663 hasConceptScore W2078174663C111337013 @default.
- W2078174663 hasConceptScore W2078174663C121332964 @default.
- W2078174663 hasConceptScore W2078174663C138885662 @default.
- W2078174663 hasConceptScore W2078174663C150194340 @default.
- W2078174663 hasConceptScore W2078174663C153911025 @default.
- W2078174663 hasConceptScore W2078174663C179926584 @default.
- W2078174663 hasConceptScore W2078174663C18231593 @default.
- W2078174663 hasConceptScore W2078174663C185544564 @default.
- W2078174663 hasConceptScore W2078174663C2778128677 @default.
- W2078174663 hasConceptScore W2078174663C2778575167 @default.
- W2078174663 hasConceptScore W2078174663C29512474 @default.
- W2078174663 hasConceptScore W2078174663C3675279 @default.
- W2078174663 hasConceptScore W2078174663C41895202 @default.
- W2078174663 hasConceptScore W2078174663C54355233 @default.
- W2078174663 hasConceptScore W2078174663C86339819 @default.
- W2078174663 hasConceptScore W2078174663C86803240 @default.
- W2078174663 hasIssue "1" @default.
- W2078174663 hasLocation W20781746631 @default.
- W2078174663 hasLocation W20781746632 @default.
- W2078174663 hasLocation W20781746633 @default.
- W2078174663 hasOpenAccess W2078174663 @default.
- W2078174663 hasPrimaryLocation W20781746631 @default.
- W2078174663 hasRelatedWork W1570674964 @default.
- W2078174663 hasRelatedWork W1990074866 @default.
- W2078174663 hasRelatedWork W1997340004 @default.
- W2078174663 hasRelatedWork W2009966535 @default.
- W2078174663 hasRelatedWork W2016208261 @default.
- W2078174663 hasRelatedWork W2047526536 @default.
- W2078174663 hasRelatedWork W2078174663 @default.
- W2078174663 hasRelatedWork W2091949613 @default.
- W2078174663 hasRelatedWork W2093417190 @default.
- W2078174663 hasRelatedWork W2463066592 @default.
- W2078174663 hasVolume "13" @default.
- W2078174663 isParatext "false" @default.
- W2078174663 isRetracted "false" @default.
- W2078174663 magId "2078174663" @default.
- W2078174663 workType "article" @default.