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- W2078175178 abstract "Two genetically distinct classes of meropenem-low-susceptibility <i>Pseudomonas oaeruginosa</i> PA02152 mutants, which arose spontaneously, were isolated. Two meropenem resistance genes, <i>mpmA</i> and <i>mpmB</i>, were mapped near <i>ilvB/C</i> and <i>proC</i>, respectively, on the <i>P. aeruginosa</i> PAO chromosome. The mpmA was thought to be identical to <i>oprD2</i> because of the cross-resistance to carbapenems and the association with the loss of the outer membrane protein D2 (OprD2). The <i>mpmB</i> mutation conferred a 4-fold increase in resistance to meropenem, and cross-resistance to various types of antimicrobial agents, e.g. carbenicillin, norfloxacin and chloramphenicol. However, the <i>mpmB</i> mutant was susceptible to imipenem. This mutant still possessed OprD2 and showed increased expression of a 48-kD outer membrane protein, although its profiles of Β-lactamase activity and affinities of penicillin-binding proteins for Β-lactams were indistinguishable from those of the parent strain. The resistance gene <i>mpmB</i> was considered to be an allele of <i>nalB</i> (or <i>cfxB</i> or <i>oprK</i>) from the results of the transductional analysis. The mutation frequency of <i>mpmA:mpmB</i> was in the ratio of 4:1. The same results were obtained in another clinically isolated <i>P. aeruginosa</i> strain. Meropenem resistance caused by both <i>mpmA</i> and <i>mpmB</i> mutations seemed to be due to the reduction in permeability of antibiotics through the outer membrane. These findings suggest a new pathway for the translocation of meropenem other than that mediated by OprD2 across the outer membrane. Thus, meropenem showed about 4- to 8-fold higher activity than imipenem against OprD2-deficient <i>P. aeruginosa</i>." @default.
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- W2078175178 title "Meropenem Resistance in <i>Pseudomonas aeruginosa</i>" @default.
- W2078175178 doi "https://doi.org/10.1159/000239421" @default.
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