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• W2078178981 startingPage "1009" @default.
• W2078178981 abstract "Francisella tularensis , the causative agent of tularemia, is one of the most infectious bacterial pathogens known and is a category A select agent. We created a sequence-defined, near-saturation transposon mutant library of F. tularensis novicida , a subspecies that causes a tularemia-like disease in rodents. The library consists of 16,508 unique insertions, an average of >9 insertions per gene, which is a coverage nearly twice that of the greatest previously achieved for any bacterial species. Insertions were recovered in 84% (1,490) of the predicted genes. To achieve high coverage, it was necessary to construct transposons carrying an endogenous Francisella promoter to drive expression of antibiotic resistance. An analysis of genes lacking (or with few) insertions identified nearly 400 candidate essential genes, most of which are likely to be required for growth on rich medium and which represent potential therapeutic targets. To facilitate genome-scale screening using the mutant collection, we assembled a sublibrary made up of two purified mutants per gene. The library provides a resource for virtually complete identification of genes involved in virulence and other nonessential processes." @default.
• W2078178981 created "2016-06-24" @default.
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• W2078178981 date "2007-01-16" @default.
• W2078178981 modified "2023-10-12" @default.
• W2078178981 title "A comprehensive transposon mutant library of <i>Francisella novicida</i> , a bioweapon surrogate" @default.
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• W2078178981 doi "https://doi.org/10.1073/pnas.0606713104" @default.
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