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- W2078180858 abstract "A method for the determination of L-697, 661, a human immunodeficiency virus type 1 reverse transcriptase inhibitor, and its 6-hydroxy metabolite in plasma is described. Following analyte isolation via solid phase extraction, samples are analyzed by HPLC using a column switching system. Column switching allows each analyte to be simultaneously analyzed under isocratic reverse phase conditions in a run time of 21 minutes. The assay was linear in the concentration range of 10–500 ng/mL for each analyte when 1 mL aliquots of plasma were extracted. The assay has been fully validated and utilized for human pharmacokinetic studies." @default.
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- W2078180858 date "1994-07-01" @default.
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- W2078180858 title "The simultaneous determination of L-697, 661, a HIV-1 specific reverse transcriptase inhibitor, and its 6-hydroxy metabolite in human plasma via column-switching high performance liquid chromatography" @default.
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- W2078180858 doi "https://doi.org/10.1007/bf02320463" @default.
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