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- W2078190469 endingPage "15529" @default.
- W2078190469 startingPage "15512" @default.
- W2078190469 abstract "Microglia are the resident macrophages of the central nervous system (CNS) and play an important role in neuronal recovery by scavenging damaged neurons. However, overactivation of microglia leads to neuronal death that is associated with CNS disorders. Therefore, regulation of microglial activation has been suggested to be an important target for treatment of CNS diseases. In the present study, we investigated the beneficial effect of resveratrol, a natural phenol with antioxidant effects, in the microglial cell line, BV2, in a model of hypoxia injury. Resveratrol suppressed the mRNA expression of the pro-inflammatory molecule, tumor necrosis factor-α, and promoted the mRNA expression of the anti-inflammatory molecule, interleukin-10, in BV2 microglia under hypoxic conditions. In addition, resveratrol inhibited the activation of the transcription factor, nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB), which is upstream in the control of inflammatory reactions in hypoxia-injured BV2 microglia. Moreover, resveratrol promoted the expression of brain-derived neurotrophic factor (BDNF) in BV2 microglia under hypoxic stress. Overall, resveratrol may promote the beneficial function of microglia in ischemic brain injury." @default.
- W2078190469 created "2016-06-24" @default.
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- W2078190469 date "2014-09-02" @default.
- W2078190469 modified "2023-10-16" @default.
- W2078190469 title "Resveratrol Induces the Expression of Interleukin-10 and Brain-Derived Neurotrophic Factor in BV2 Microglia under Hypoxia" @default.
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- W2078190469 doi "https://doi.org/10.3390/ijms150915512" @default.
- W2078190469 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4200860" @default.
- W2078190469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25184950" @default.
- W2078190469 hasPublicationYear "2014" @default.
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