FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078192920> ?p ?o ?g. }

• W2078192920 endingPage "5157" @default.
• W2078192920 startingPage "5151" @default.
• W2078192920 abstract "The effect of a 17-kringle form of recombinant apo(a) [r-apo(a)] on in vitro fibrin clot lysis was studied. In these assays, fibrin clots were formed in the wells of microtiter plates, and lysis of the clots was monitored by measurement of the turbidity at 405 nm. The results indicate that r-apo(a) produces a dose-dependent antifibrinolytic effect in clots formed using either purified components or barium-adsorbed plasma. This effect was found to be independent of clot structure, since lysis of clots formed using both high and low concentrations of thrombin was prolonged by r-apo(a) to the same extent. The two components of the antifibrinolytic effect of r-apo(a) were determined to be (i) attenuation of tPA-mediated plasminogen activation (the major component) and (ii) inhibition of plasmin degradation of fibrin, although r-apo(a) did not directly attenuate plasmin activity, as measured by S-2251 hydrolysis. r-Apo(a) interfered most substantially with tPA-mediated activation of Glu-plasminogen and less substantially with tPA-mediated Lys-plasminogen activation and urokinase-mediated activation of plasminogen. In summary, we have demonstrated that apo(a) is able to attenuate fibrin clot lysis in vitro, primarily as a consequence of the interference by apo(a) with tPA-mediated Glu-plasminogen activation. These studies illuminate possible mechanisms by which Lp(a) may contribute to the development of vascular disease in vivo." @default.
• W2078192920 created "2016-06-24" @default.
• W2078192920 creator A5036043110 @default.
• W2078192920 creator A5038557633 @default.
• W2078192920 creator A5051123834 @default.
• W2078192920 creator A5051645334 @default.
• W2078192920 date "1995-04-18" @default.
• W2078192920 modified "2023-10-17" @default.
• W2078192920 title "Antifibrinolytic Effect of Recombinant Apolipoprotein(a) in Vitro Is Primarily Due to Attenuation of tPA-Mediated Glu-Plasminogen Activation" @default.
• W2078192920 cites W1491117599 @default.
• W2078192920 cites W1493150376 @default.
• W2078192920 cites W1512983489 @default.
• W2078192920 cites W1534448823 @default.
• W2078192920 cites W1549967714 @default.
• W2078192920 cites W1569381450 @default.
• W2078192920 cites W1604425981 @default.
• W2078192920 cites W1961340888 @default.
• W2078192920 cites W1966206590 @default.
• W2078192920 cites W1975754777 @default.
• W2078192920 cites W1976186392 @default.
• W2078192920 cites W1986030167 @default.
• W2078192920 cites W1989069669 @default.
• W2078192920 cites W1994885000 @default.
• W2078192920 cites W2001532153 @default.
• W2078192920 cites W2001691760 @default.
• W2078192920 cites W2010105576 @default.
• W2078192920 cites W2010782167 @default.
• W2078192920 cites W2012098057 @default.
• W2078192920 cites W2019849071 @default.
• W2078192920 cites W2024101583 @default.
• W2078192920 cites W2026873073 @default.
• W2078192920 cites W2028895755 @default.
• W2078192920 cites W2029458605 @default.
• W2078192920 cites W2030308708 @default.
• W2078192920 cites W2036170644 @default.
• W2078192920 cites W2040278638 @default.
• W2078192920 cites W2044474186 @default.
• W2078192920 cites W2044595268 @default.
• W2078192920 cites W2046913628 @default.
• W2078192920 cites W2055783796 @default.
• W2078192920 cites W2062501060 @default.
• W2078192920 cites W2070221317 @default.
• W2078192920 cites W2073968756 @default.
• W2078192920 cites W2084667370 @default.
• W2078192920 cites W2087316197 @default.
• W2078192920 cites W2088347508 @default.
• W2078192920 cites W2088826683 @default.
• W2078192920 cites W2089836570 @default.
• W2078192920 cites W2095224270 @default.
• W2078192920 cites W2118645446 @default.
• W2078192920 cites W2136145860 @default.
• W2078192920 cites W2159077766 @default.
• W2078192920 cites W2160741225 @default.
• W2078192920 cites W2236214807 @default.
• W2078192920 cites W2277227278 @default.
• W2078192920 cites W2346305890 @default.
• W2078192920 cites W2399464812 @default.
• W2078192920 cites W2411993677 @default.
• W2078192920 cites W25173866 @default.
• W2078192920 cites W4249149432 @default.
• W2078192920 cites W4254670328 @default.
• W2078192920 doi "https://doi.org/10.1021/bi00015a028" @default.
• W2078192920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7711034" @default.
• W2078192920 hasPublicationYear "1995" @default.
• W2078192920 type Work @default.
• W2078192920 sameAs 2078192920 @default.
• W2078192920 citedByCount "53" @default.
• W2078192920 countsByYear W20781929202012 @default.
• W2078192920 countsByYear W20781929202013 @default.
• W2078192920 countsByYear W20781929202014 @default.
• W2078192920 countsByYear W20781929202015 @default.
• W2078192920 countsByYear W20781929202016 @default.
• W2078192920 countsByYear W20781929202017 @default.
• W2078192920 countsByYear W20781929202018 @default.
• W2078192920 countsByYear W20781929202019 @default.
• W2078192920 countsByYear W20781929202020 @default.
• W2078192920 countsByYear W20781929202022 @default.
• W2078192920 countsByYear W20781929202023 @default.
• W2078192920 crossrefType "journal-article" @default.
• W2078192920 hasAuthorship W2078192920A5036043110 @default.
• W2078192920 hasAuthorship W2078192920A5038557633 @default.
• W2078192920 hasAuthorship W2078192920A5051123834 @default.
• W2078192920 hasAuthorship W2078192920A5051645334 @default.
• W2078192920 hasConcept C12554922 @default.
• W2078192920 hasConcept C126322002 @default.
• W2078192920 hasConcept C141071460 @default.
• W2078192920 hasConcept C150903083 @default.
• W2078192920 hasConcept C153911025 @default.
• W2078192920 hasConcept C181199279 @default.
• W2078192920 hasConcept C185592680 @default.
• W2078192920 hasConcept C202751555 @default.
• W2078192920 hasConcept C203014093 @default.
• W2078192920 hasConcept C207001950 @default.
• W2078192920 hasConcept C2776825266 @default.
• W2078192920 hasConcept C2776892390 @default.
• W2078192920 hasConcept C2778775115 @default.
• W2078192920 hasConcept C2779637338 @default.
• W2078192920 hasConcept C2780799893 @default.

• next