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• W2078198153 abstract "Serotonin (5-HT) is a neurotransmitter that also functions as a hormone and a growth factor. 5-HT is involved in numerous physiological actions and displays complex pharmacological properties. As a growth factor, 5-HT plays a role in cell proliferation and differentiation of neuronal and nonneuronal tissue and it transduces its signals through more than fourteen subtypes of 5-HT receptors. Since determination of the expression and distribution is important for understanding the role of the 5-HT receptors, we have developed an RNase protection assay (RPA) that allows the simultaneous analysis of 5-HT_2AR, 5-HT_2BR, and 5-HT_2CR per sample of RNA. This multiprobe set also comprises probes for two house-keeping genes, L32 and GAPDH, which control for sample-loading errors. Using this RPA probe set, we have examined the relative expression of 5-HT_2AR, 5-HT_2BR, and 5-HT_2CR in rat embryos inclusively from embryonic day (ED) 9 to 21 of development. Our data indicate that 5-HT_2AR levels gradually increased from ED11 to ED21. The expression of 5-HT_2BR was decreased between ED9 to ED11 then remained relatively constant through ED21. 5-HT_2CR was initially expressed at residual levels between ED9 and ED12 but dramatically increased to a peak level at ED13, then decreased by ED17. Expression of the 5-HT₂ receptors in these tissues was confirmed independently by RT-PCR indicating that there is developmental regulation in the expression of these receptors. The 5-HT₂R multiprobe assay will be useful for detecting relative changes in the expression of these receptors in developmental, normal and pathological tissues as well as for monitoring relative changes in expression resulting from the use of pharmaceutical agents." @default.
• W2078198153 created "2016-06-24" @default.
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• W2078198153 date "1999-01-01" @default.
• W2078198153 modified "2023-10-07" @default.
• W2078198153 title "Differential Expression of Serotonin 5-HT₂ Receptors during Rat Embryogenesis" @default.
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• W2078198153 doi "https://doi.org/10.1159/000017362" @default.
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