Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078199739> ?p ?o ?g. }
- W2078199739 endingPage "42" @default.
- W2078199739 startingPage "235" @default.
- W2078199739 abstract "Herpes simplex viruses (HSVs) display affinity for cell-surface heparan sulfate proteoglycans with biological relevance in virus entry. Here, we exploit an approach to inhibiting HSV infection by using a sulfated fucoidan, and a guluronic acid-rich alginate derived from Sargassum tenerrimum, mimicking the active domain of the entry receptor. These macromolecules have apparent molecular masses of 30+/-5 and 26+/-5 kDa, respectively. They and their chemically sulfated derivatives showed activity against herpes simplex virus type 1 (HSV-1). Their inhibitory concentration 50% (IC(50)) values were in the range 0.5-15 microg/ml and they lacked cytotoxicity at concentrations up to 1000 microg/ml. The anti-HSV activity increased with increasing sulfate ester content. Our results suggest the feasibility of inhibiting HSV infection by blocking viral entry with polysaccharide having specific structure." @default.
- W2078199739 created "2016-06-24" @default.
- W2078199739 creator A5017420290 @default.
- W2078199739 creator A5019961280 @default.
- W2078199739 creator A5025446554 @default.
- W2078199739 creator A5066201130 @default.
- W2078199739 creator A5070419464 @default.
- W2078199739 date "2010-02-01" @default.
- W2078199739 modified "2023-10-16" @default.
- W2078199739 title "Polysaccharides from Sargassum tenerrimum: structural features, chemical modification and anti-viral activity." @default.
- W2078199739 cites W187964413 @default.
- W2078199739 cites W1963852477 @default.
- W2078199739 cites W1968834637 @default.
- W2078199739 cites W1978235844 @default.
- W2078199739 cites W1986574293 @default.
- W2078199739 cites W1989625938 @default.
- W2078199739 cites W1990989065 @default.
- W2078199739 cites W1991205666 @default.
- W2078199739 cites W1993731031 @default.
- W2078199739 cites W1995239838 @default.
- W2078199739 cites W1996714882 @default.
- W2078199739 cites W1997221411 @default.
- W2078199739 cites W2001371234 @default.
- W2078199739 cites W2006799975 @default.
- W2078199739 cites W2007918881 @default.
- W2078199739 cites W2010911897 @default.
- W2078199739 cites W2011169355 @default.
- W2078199739 cites W2024383984 @default.
- W2078199739 cites W2026901280 @default.
- W2078199739 cites W2028144465 @default.
- W2078199739 cites W2033374941 @default.
- W2078199739 cites W2040662056 @default.
- W2078199739 cites W2042598937 @default.
- W2078199739 cites W2055465469 @default.
- W2078199739 cites W2068074325 @default.
- W2078199739 cites W2076714252 @default.
- W2078199739 cites W2080442263 @default.
- W2078199739 cites W2081007549 @default.
- W2078199739 cites W2092235135 @default.
- W2078199739 cites W2093333593 @default.
- W2078199739 cites W2096213645 @default.
- W2078199739 cites W2097903159 @default.
- W2078199739 cites W2100187632 @default.
- W2078199739 cites W2108441155 @default.
- W2078199739 cites W2120078856 @default.
- W2078199739 cites W2135278398 @default.
- W2078199739 cites W2142240729 @default.
- W2078199739 cites W2154272456 @default.
- W2078199739 cites W2160010002 @default.
- W2078199739 cites W2163012117 @default.
- W2078199739 cites W2163668546 @default.
- W2078199739 cites W2302854153 @default.
- W2078199739 cites W2334917064 @default.
- W2078199739 cites W3027618595 @default.
- W2078199739 cites W4211123708 @default.
- W2078199739 cites W4229510242 @default.
- W2078199739 doi "https://doi.org/10.1016/j.phytochem.2009.10.014" @default.
- W2078199739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19931103" @default.
- W2078199739 hasPublicationYear "2010" @default.
- W2078199739 type Work @default.
- W2078199739 sameAs 2078199739 @default.
- W2078199739 citedByCount "138" @default.
- W2078199739 countsByYear W20781997392012 @default.
- W2078199739 countsByYear W20781997392013 @default.
- W2078199739 countsByYear W20781997392014 @default.
- W2078199739 countsByYear W20781997392015 @default.
- W2078199739 countsByYear W20781997392016 @default.
- W2078199739 countsByYear W20781997392017 @default.
- W2078199739 countsByYear W20781997392018 @default.
- W2078199739 countsByYear W20781997392019 @default.
- W2078199739 countsByYear W20781997392020 @default.
- W2078199739 countsByYear W20781997392021 @default.
- W2078199739 countsByYear W20781997392022 @default.
- W2078199739 countsByYear W20781997392023 @default.
- W2078199739 crossrefType "journal-article" @default.
- W2078199739 hasAuthorship W2078199739A5017420290 @default.
- W2078199739 hasAuthorship W2078199739A5019961280 @default.
- W2078199739 hasAuthorship W2078199739A5025446554 @default.
- W2078199739 hasAuthorship W2078199739A5066201130 @default.
- W2078199739 hasAuthorship W2078199739A5070419464 @default.
- W2078199739 hasConcept C100817775 @default.
- W2078199739 hasConcept C109316439 @default.
- W2078199739 hasConcept C116073593 @default.
- W2078199739 hasConcept C140704245 @default.
- W2078199739 hasConcept C1491633281 @default.
- W2078199739 hasConcept C155138218 @default.
- W2078199739 hasConcept C159047783 @default.
- W2078199739 hasConcept C185592680 @default.
- W2078199739 hasConcept C18903297 @default.
- W2078199739 hasConcept C202751555 @default.
- W2078199739 hasConcept C2522874641 @default.
- W2078199739 hasConcept C2775909754 @default.
- W2078199739 hasConcept C2778041096 @default.
- W2078199739 hasConcept C2778317458 @default.
- W2078199739 hasConcept C2778760044 @default.
- W2078199739 hasConcept C2781196997 @default.
- W2078199739 hasConcept C54355233 @default.
- W2078199739 hasConcept C55493867 @default.