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• W2078199984 abstract "The ability to expand human neural precursor cells in vitro offers new possibilities for future cell therapies. However, concern over immunologically based rejection of in vitro-expanded human neural cells confounds their use as donor cells. Here, we demonstrate that the expression of human leukocyte antigen (HLA) class I and II molecules, but not the co-stimulatory proteins CD40, CD80 and CD86, substantially increase during expansion of neurospheres. Furthermore, peripheral lymphocytes were unresponsive when co-cultured with in vitro-expanded neural cells. Taken together, these results suggest a low immunogenicity of these cultured human neural cells despite HLA incompatibility and high HLA expression." @default.
• W2078199984 created "2016-06-24" @default.
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• W2078199984 date "2005-04-01" @default.
• W2078199984 modified "2023-10-07" @default.
• W2078199984 title "Low immunogenicity of in vitro-expanded human neural cells despite high MHC expression" @default.
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• W2078199984 doi "https://doi.org/10.1016/j.jneuroim.2004.11.016" @default.
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