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- W2078201819 abstract "The electrophysiologic actions of epinephrine (10−9M, 10−8M, and 10−7M) were evaluated in canine Purkinie fibers pretreated with the class III antiarrhythmic drugs clofilium (10−7M) or d,l-sotalol (10−6M). Clofilium and d,l-sotalol prolonged action potential duration at 50% and 90% of repolarization without provoking early afterdepolarization (EAD) or delayed afterdepolarization (DAD). Subsequent administration of epinephrine provoked both bradycardia-dependent EADs and tachycardia-dependent DADs in clofiliumtreated Purkinje fibers, with predominantly EADs observed in d,l-sotaloltreated Purkinje fibers. A temporary increase in Ca0+2 from 1.35 mM to 5 mM suppressed both EADs and DADs. The data demonstrate facilitation of epinephrine-induced EADs and DADs by class III antiarrhythmic drugs. The acute suppression of both EADs and DADs observed following an acute increase in Ca0+2 suggests inward Na+-Ca0+2 exchange current as a basis for both EADs and DADs observed in the presence of class III antiarrhythmic drugs and epinephrine." @default.
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- W2078201819 title "Facilitation of epinephrine-induced afterdepolarizations by class III antiarrhythmic drugs" @default.
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- W2078201819 doi "https://doi.org/10.1016/s0022-0736(97)80007-6" @default.
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