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- W2078202263 startingPage "e77141" @default.
- W2078202263 abstract "Structural motions along a reaction pathway hold the secret about how a biological macromolecule functions. If each static structure were considered as a snapshot of the protein molecule in action, a large collection of structures would constitute a multidimensional conformational space of an enormous size. Here I present a joint analysis of hundreds of known structures of human hemoglobin in the Protein Data Bank. By applying singular value decomposition to distance matrices of these structures, I demonstrate that this large collection of structural snapshots, derived under a wide range of experimental conditions, arrange orderly along a reaction pathway. The structural motions along this extensive trajectory, including several helical transformations, arrive at a reverse engineered mechanism of the cooperative machinery (Ren, companion article), and shed light on pathological properties of the abnormal homotetrameric hemoglobins from α-thalassemia. This method of meta-analysis provides a general approach to structural dynamics based on static protein structures in this post genomics era." @default.
- W2078202263 created "2016-06-24" @default.
- W2078202263 creator A5072655788 @default.
- W2078202263 date "2013-11-11" @default.
- W2078202263 modified "2023-10-16" @default.
- W2078202263 title "Reaction Trajectory Revealed by a Joint Analysis of Protein Data Bank" @default.
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- W2078202263 doi "https://doi.org/10.1371/journal.pone.0077141" @default.
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