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- W2078202582 endingPage "944" @default.
- W2078202582 startingPage "932" @default.
- W2078202582 abstract "As public microarray repositories rapidly accumulate gene expression data, these resources contain increasingly valuable information about cellular processes in human biology. This presents a unique opportunity for intelligent data mining methods to extract information about the transcriptional modules underlying these biological processes. Modeling cellular gene expression as a combination of functional modules, we use independent component analysis (ICA) to derive 423 fundamental components of human biology from a 9395-array compendium of heterogeneous expression data. Annotation using the Gene Ontology (GO) suggests that while some of these components represent known biological modules, others may describe biology not well characterized by existing manually-curated ontologies. In order to understand the biological functions represented by these modules, we investigate the mechanism of the preclinical anti-cancer drug parthenolide (PTL) by analyzing the differential expression of our fundamental components. Our method correctly identifies known pathways and predicts that N-glycan biosynthesis and T-cell receptor signaling may contribute to PTL response. The fundamental gene modules we describe have the potential to provide pathway-level insight into new gene expression datasets." @default.
- W2078202582 created "2016-06-24" @default.
- W2078202582 creator A5006056135 @default.
- W2078202582 creator A5025941162 @default.
- W2078202582 creator A5036160602 @default.
- W2078202582 creator A5084043782 @default.
- W2078202582 date "2010-12-01" @default.
- W2078202582 modified "2023-10-18" @default.
- W2078202582 title "Independent component analysis: Mining microarray data for fundamental human gene expression modules" @default.
- W2078202582 cites W1522779995 @default.
- W2078202582 cites W1932560099 @default.
- W2078202582 cites W1967537433 @default.
- W2078202582 cites W1970477403 @default.
- W2078202582 cites W1988297989 @default.
- W2078202582 cites W1995243908 @default.
- W2078202582 cites W1997195198 @default.
- W2078202582 cites W2007194591 @default.
- W2078202582 cites W2011717936 @default.
- W2078202582 cites W2013933356 @default.
- W2078202582 cites W2017660057 @default.
- W2078202582 cites W2018699543 @default.
- W2078202582 cites W2020541351 @default.
- W2078202582 cites W2022126491 @default.
- W2078202582 cites W2023518751 @default.
- W2078202582 cites W2026970599 @default.
- W2078202582 cites W2027514721 @default.
- W2078202582 cites W2033853342 @default.
- W2078202582 cites W2037562549 @default.
- W2078202582 cites W2043399591 @default.
- W2078202582 cites W2049671131 @default.
- W2078202582 cites W2050748701 @default.
- W2078202582 cites W2053126761 @default.
- W2078202582 cites W2055350603 @default.
- W2078202582 cites W2057653416 @default.
- W2078202582 cites W2061038526 @default.
- W2078202582 cites W2061460326 @default.
- W2078202582 cites W2065741295 @default.
- W2078202582 cites W2066543052 @default.
- W2078202582 cites W2068156739 @default.
- W2078202582 cites W2069645361 @default.
- W2078202582 cites W2070476729 @default.
- W2078202582 cites W2076784218 @default.
- W2078202582 cites W2079105976 @default.
- W2078202582 cites W2080202391 @default.
- W2078202582 cites W2080400869 @default.
- W2078202582 cites W2081098333 @default.
- W2078202582 cites W2082207932 @default.
- W2078202582 cites W2090664364 @default.
- W2078202582 cites W2092378048 @default.
- W2078202582 cites W2092868756 @default.
- W2078202582 cites W2093186323 @default.
- W2078202582 cites W2095956310 @default.
- W2078202582 cites W2101351842 @default.
- W2078202582 cites W2103453943 @default.
- W2078202582 cites W2111840226 @default.
- W2078202582 cites W2112464428 @default.
- W2078202582 cites W2115214814 @default.
- W2078202582 cites W2115503758 @default.
- W2078202582 cites W2116961371 @default.
- W2078202582 cites W2120024428 @default.
- W2078202582 cites W2120865735 @default.
- W2078202582 cites W2121604817 @default.
- W2078202582 cites W2121905508 @default.
- W2078202582 cites W2122136196 @default.
- W2078202582 cites W2125512776 @default.
- W2078202582 cites W2127718009 @default.
- W2078202582 cites W2130410032 @default.
- W2078202582 cites W2130790725 @default.
- W2078202582 cites W2135230352 @default.
- W2078202582 cites W2139600676 @default.
- W2078202582 cites W2141224535 @default.
- W2078202582 cites W2142720308 @default.
- W2078202582 cites W2143274936 @default.
- W2078202582 cites W2144544802 @default.
- W2078202582 cites W2146264532 @default.
- W2078202582 cites W2146967305 @default.
- W2078202582 cites W2147307155 @default.
- W2078202582 cites W2148541040 @default.
- W2078202582 cites W2149609961 @default.
- W2078202582 cites W2150702851 @default.
- W2078202582 cites W2150926065 @default.
- W2078202582 cites W2152320972 @default.
- W2078202582 cites W2153073444 @default.
- W2078202582 cites W2155120241 @default.
- W2078202582 cites W2155386706 @default.
- W2078202582 cites W2158128075 @default.
- W2078202582 cites W2159460045 @default.
- W2078202582 cites W2159703006 @default.
- W2078202582 cites W2160572762 @default.
- W2078202582 cites W2160697532 @default.
- W2078202582 cites W2164910356 @default.
- W2078202582 cites W2165114168 @default.
- W2078202582 cites W2165151093 @default.
- W2078202582 cites W2167190345 @default.
- W2078202582 cites W2170989872 @default.
- W2078202582 cites W2331176038 @default.
- W2078202582 cites W4313347901 @default.
- W2078202582 doi "https://doi.org/10.1016/j.jbi.2010.07.001" @default.