Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078207148> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2078207148 endingPage "440" @default.
- W2078207148 startingPage "436" @default.
- W2078207148 abstract "The aim of this study was to investigate the expression of hepatocyte growth factor (HGF) and its receptor (c-met) during bladder tumorigenesis.HGF and c-met expression were analyzed immunohistochemically in matched samples of normal, dysplastic, and carcinoma specimens from 49 human bladders resected at the time of radical cystectomy for nonmetastatic transitional cell carcinoma (TCC). The tumors were composed of papillary (n = 22), nodular (n = 16) or mixed papillary and nodular (mixed; n = 11) components.The normal urothelium showed no significant immunoreactivity to HGF. Expression of HGF was observed in 45.5%, 77.3% and 90.9% of specimens demonstrating mild, moderate, and severe dysplastic lesions adjacent to papillary TCCs, respectively, whereas all of the papillary TCC samples were positive for HGF. No immunoreactivity for HGF was found in dysplastic lesions from nodular tumors, and only 2 specimens had positive immunostaining for HGF in the tumor areas (1 showed weak immunostaining and 1 showed HGF immunostaining only in the deeper invasive compartment). Additionally, 3 nodular lesions taken from mixed tumors showed weak immunostaining for HGF while the concurrent papillary lesions were HGF-positive. There was a significant difference of HGF immunoreactivity between papillary and nodular tumors (P < 0.01). c-met immunostaining was consistently detected in all specimens. HGF and c-met immunoreactivity did not significantly correlate with tumor stage and grade, nor with overall patient survival irrespective of the tumor growth pattern.These results suggest that HGF expression may play a significant role in the development of papillary TCC." @default.
- W2078207148 created "2016-06-24" @default.
- W2078207148 creator A5028522883 @default.
- W2078207148 creator A5043715211 @default.
- W2078207148 creator A5045552730 @default.
- W2078207148 creator A5059752985 @default.
- W2078207148 creator A5084681260 @default.
- W2078207148 date "1998-09-01" @default.
- W2078207148 modified "2023-09-26" @default.
- W2078207148 title "Differential Expression of Hepatocyte Growth Factor in Papillary and Nodular Tumors of the Bladder" @default.
- W2078207148 cites W1545126968 @default.
- W2078207148 cites W1969934450 @default.
- W2078207148 cites W1977029863 @default.
- W2078207148 cites W2005882721 @default.
- W2078207148 cites W2052915894 @default.
- W2078207148 cites W2060655489 @default.
- W2078207148 cites W2121562333 @default.
- W2078207148 cites W2151005088 @default.
- W2078207148 cites W2162396472 @default.
- W2078207148 cites W4231698332 @default.
- W2078207148 cites W4239305338 @default.
- W2078207148 cites W4254820703 @default.
- W2078207148 doi "https://doi.org/10.1111/j.1442-2042.1998.tb00383.x" @default.
- W2078207148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9781430" @default.
- W2078207148 hasPublicationYear "1998" @default.
- W2078207148 type Work @default.
- W2078207148 sameAs 2078207148 @default.
- W2078207148 citedByCount "16" @default.
- W2078207148 countsByYear W20782071482014 @default.
- W2078207148 countsByYear W20782071482016 @default.
- W2078207148 countsByYear W20782071482022 @default.
- W2078207148 crossrefType "journal-article" @default.
- W2078207148 hasAuthorship W2078207148A5028522883 @default.
- W2078207148 hasAuthorship W2078207148A5043715211 @default.
- W2078207148 hasAuthorship W2078207148A5045552730 @default.
- W2078207148 hasAuthorship W2078207148A5059752985 @default.
- W2078207148 hasAuthorship W2078207148A5084681260 @default.
- W2078207148 hasConcept C126322002 @default.
- W2078207148 hasConcept C142724271 @default.
- W2078207148 hasConcept C170493617 @default.
- W2078207148 hasConcept C204232928 @default.
- W2078207148 hasConcept C2776996007 @default.
- W2078207148 hasConcept C2777540882 @default.
- W2078207148 hasConcept C2779762690 @default.
- W2078207148 hasConcept C2780467284 @default.
- W2078207148 hasConcept C2781308585 @default.
- W2078207148 hasConcept C4224716 @default.
- W2078207148 hasConcept C71924100 @default.
- W2078207148 hasConceptScore W2078207148C126322002 @default.
- W2078207148 hasConceptScore W2078207148C142724271 @default.
- W2078207148 hasConceptScore W2078207148C170493617 @default.
- W2078207148 hasConceptScore W2078207148C204232928 @default.
- W2078207148 hasConceptScore W2078207148C2776996007 @default.
- W2078207148 hasConceptScore W2078207148C2777540882 @default.
- W2078207148 hasConceptScore W2078207148C2779762690 @default.
- W2078207148 hasConceptScore W2078207148C2780467284 @default.
- W2078207148 hasConceptScore W2078207148C2781308585 @default.
- W2078207148 hasConceptScore W2078207148C4224716 @default.
- W2078207148 hasConceptScore W2078207148C71924100 @default.
- W2078207148 hasIssue "5" @default.
- W2078207148 hasLocation W20782071481 @default.
- W2078207148 hasLocation W20782071482 @default.
- W2078207148 hasOpenAccess W2078207148 @default.
- W2078207148 hasPrimaryLocation W20782071481 @default.
- W2078207148 hasRelatedWork W1964006210 @default.
- W2078207148 hasRelatedWork W1973337283 @default.
- W2078207148 hasRelatedWork W2030774815 @default.
- W2078207148 hasRelatedWork W2078207148 @default.
- W2078207148 hasRelatedWork W2087512526 @default.
- W2078207148 hasRelatedWork W2131028770 @default.
- W2078207148 hasRelatedWork W2186098084 @default.
- W2078207148 hasRelatedWork W2413359840 @default.
- W2078207148 hasRelatedWork W2414116753 @default.
- W2078207148 hasRelatedWork W3046579438 @default.
- W2078207148 hasVolume "5" @default.
- W2078207148 isParatext "false" @default.
- W2078207148 isRetracted "false" @default.
- W2078207148 magId "2078207148" @default.
- W2078207148 workType "article" @default.