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- W2078207929 abstract "Abstract The effects of a selective β2-blocker (ICI 118,551) on hepatic haemodynamics were studied in cirrhotic and non-cirrhotic rats. Infusions of 10 and 20 μg (kg body wt)−1 min−1 β2-blocker (in cirrhotic and non-cirrhotic rats) significantly reduced portal pressure, portal venous flow and liver blood flow without altering heart rate. Splanchnic vascular resistance was significantly increased following infusions of 10 and 20 μg (kg body wt)−1 min−1 β2-blocker. An intraportal injection of β2-blocker (10 μg body wt)−1 or hepatic artery ligation lowered portal pressure by approximately the same magnitude. Intraportal injection of β2-blocker after hepatic artery ligation did not further reduce portal pressure. The results indicate that a selective β2-blocker reduces portal pressure by a combination of increased splanchnic vascular resistance and hepatic arterial resistance. It is concluded that a selective β2-blocker may be of clinical value in the long-term managements of portal hypertension." @default.
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- W2078207929 date "1985-08-01" @default.
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- W2078207929 title "Effects of a selective β2-blocker (ICI 118,551) on hepatic haemodynamics in the cirrhotic and non-cirrhotic rat" @default.
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- W2078207929 doi "https://doi.org/10.1002/bjs.1800720824" @default.
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