Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078209159> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2078209159 endingPage "214" @default.
- W2078209159 startingPage "210" @default.
- W2078209159 abstract "The present study describes the use of a new polyacrolein microsphere (acrobead) protein A column. This method enables immunomodulation by the perfusion of whole blood. The efficacy of the column and its adverse effects following perfusion of blood of patients with immune thrombocytopenic purpura (ITP) or malignancies were investigated. Concurrent experiments in which blood was perfused through an acrobead lactoglobulin column were carried out. Cellular blood components were mildly affected during the procedure. A moderate decrease in platelet number, to a nadir of 90 x 10(3) per microL (90 x 10(9)/L), was documented. During the hemoperfusion of ITP patients' blood, plasma hemoglobin reached levels of 25 to 40 mg per dL, a level similar to that found in banked blood during storage. Plasma tumor necrosis factor level, which serves as an indicator of monocytic activation, increased after 90 minutes of hemoperfusion. IgG and immune complexes were removed. The specific activities (removal of mg Ig/mL bead) of acrobead protein A columns, using blood from patients with ITP or malignancies, were 4.9 and 4.5 mg IgG per mL of bead, respectively. The diminution of platelet-specific IgG in the plasma of patients with ITP was documented as well. There was no activation of the fibrinolytic system as examined by D-dimers. The use of this new technique, which incorporates the method of direct hemoperfusion, is suggested for future clinical studies." @default.
- W2078209159 created "2016-06-24" @default.
- W2078209159 creator A5018823707 @default.
- W2078209159 creator A5031423514 @default.
- W2078209159 creator A5064295156 @default.
- W2078209159 creator A5090320590 @default.
- W2078209159 date "1992-03-01" @default.
- W2078209159 modified "2023-10-14" @default.
- W2078209159 title "Evaluation of a new polyacrolein microsphere (acrobead) protein A column: an in vitro study using the blood of patients with immune thrombocytopenia or malignancies" @default.
- W2078209159 doi "https://doi.org/10.1046/j.1537-2995.1992.32392213802.x" @default.
- W2078209159 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1557800" @default.
- W2078209159 hasPublicationYear "1992" @default.
- W2078209159 type Work @default.
- W2078209159 sameAs 2078209159 @default.
- W2078209159 citedByCount "1" @default.
- W2078209159 crossrefType "journal-article" @default.
- W2078209159 hasAuthorship W2078209159A5018823707 @default.
- W2078209159 hasAuthorship W2078209159A5031423514 @default.
- W2078209159 hasAuthorship W2078209159A5064295156 @default.
- W2078209159 hasAuthorship W2078209159A5090320590 @default.
- W2078209159 hasConcept C126322002 @default.
- W2078209159 hasConcept C146957229 @default.
- W2078209159 hasConcept C1621761 @default.
- W2078209159 hasConcept C203014093 @default.
- W2078209159 hasConcept C2776738589 @default.
- W2078209159 hasConcept C2778063415 @default.
- W2078209159 hasConcept C2778917026 @default.
- W2078209159 hasConcept C2779771385 @default.
- W2078209159 hasConcept C2781123077 @default.
- W2078209159 hasConcept C71924100 @default.
- W2078209159 hasConcept C8891405 @default.
- W2078209159 hasConcept C89560881 @default.
- W2078209159 hasConcept C90924648 @default.
- W2078209159 hasConceptScore W2078209159C126322002 @default.
- W2078209159 hasConceptScore W2078209159C146957229 @default.
- W2078209159 hasConceptScore W2078209159C1621761 @default.
- W2078209159 hasConceptScore W2078209159C203014093 @default.
- W2078209159 hasConceptScore W2078209159C2776738589 @default.
- W2078209159 hasConceptScore W2078209159C2778063415 @default.
- W2078209159 hasConceptScore W2078209159C2778917026 @default.
- W2078209159 hasConceptScore W2078209159C2779771385 @default.
- W2078209159 hasConceptScore W2078209159C2781123077 @default.
- W2078209159 hasConceptScore W2078209159C71924100 @default.
- W2078209159 hasConceptScore W2078209159C8891405 @default.
- W2078209159 hasConceptScore W2078209159C89560881 @default.
- W2078209159 hasConceptScore W2078209159C90924648 @default.
- W2078209159 hasIssue "3" @default.
- W2078209159 hasLocation W20782091591 @default.
- W2078209159 hasLocation W20782091592 @default.
- W2078209159 hasOpenAccess W2078209159 @default.
- W2078209159 hasPrimaryLocation W20782091591 @default.
- W2078209159 hasRelatedWork W108197325 @default.
- W2078209159 hasRelatedWork W2017682208 @default.
- W2078209159 hasRelatedWork W2032504685 @default.
- W2078209159 hasRelatedWork W2064618322 @default.
- W2078209159 hasRelatedWork W2100269967 @default.
- W2078209159 hasRelatedWork W2148345396 @default.
- W2078209159 hasRelatedWork W2356978245 @default.
- W2078209159 hasRelatedWork W2372771645 @default.
- W2078209159 hasRelatedWork W32392874 @default.
- W2078209159 hasRelatedWork W789821843 @default.
- W2078209159 hasVolume "32" @default.
- W2078209159 isParatext "false" @default.
- W2078209159 isRetracted "false" @default.
- W2078209159 magId "2078209159" @default.
- W2078209159 workType "article" @default.