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- W2078209663 abstract "Letters15 September 1997Transdermal Nicotine for Ulcerative ColitisMichael Mogadam, MDMichael Mogadam, MDAlexandria, VA 22304Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-6-199709150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Sandborn and colleagues [1] state that their placebo-controlled trial showed that “transdermal nicotine at the highest tolerated dosage (≤22 mg/d) has a clinically significant therapeutic benefit in active ulcerative colitis after 4 weeks.” How could they make this statement if only 39% of their patients improved clinically (compared with 9% of those who received placebo)? I do not consider a 30% response (39% −9%) in ulcerative colitis to be clinically meaningful, especially because 77% of patients who received nicotine patches had various side effects; in 13%, these effects were severe enough to discontinue use of the patches.... References1. Sandborn WJ, Tremaine WJ, Offord KP, Lawson GM, Petersen BT, Batts KP, et al. Transdermal nicotine for mildly to moderately active ulcerative colitis. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1997; 126:364-71. Google Scholar Author, Article, and Disclosure InformationAuthors: Michael Mogadam, MDAffiliations: Alexandria, VA 22304 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1997Volume 127, Issue 6Page: 491KeywordsNicotineUlcerative colitis ePublished: 15 August 2000 Issue Published: 15 September 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ..." @default.
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