FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078210863> ?p ?o ?g. }

• W2078210863 endingPage "e16138" @default.
• W2078210863 startingPage "e16138" @default.
• W2078210863 abstract "MicroRNAs are short (∼22 nt) non-coding regulatory RNAs that control gene expression at the post-transcriptional level. Here the functional impact of microRNAs on cell cycle arrest during neuronal lineage differentiation of unrestricted somatic stem cells from human cord blood (USSC) was analyzed.Expression profiling revealed downregulation of microRNAs miR-17, -20a, and -106b in USSC differentiated into neuronal lineage but not in USSC differentiated into osteogenic lineage. Transfection experiments followed by Ki67 immunostainings demonstrated that each of these microRNAs was able to promote proliferation of native USSC and to prevent in part cell cycle arrest during neuronal lineage differentiation of USSC. Bioinformatic target gene predictions followed by experimental target gene validations revealed that miR-17, -20a, and -106b act in a common manner by downregulating an overlapping set of target genes mostly involved in regulation and execution of G(1)/S transition. Pro-proliferative target genes cyclinD1 (CCND1) and E2F1 as well as anti-proliferative targets CDKN1A (p21), PTEN, RB1, RBL1 (p107), RBL2 (p130) were shown as common targets for miR-17, -20a, and -106b. Furthermore, these microRNAs also downregulate WEE1 which is involved in G(2)/M transition. Most strikingly, miR-17, -20a, and -106b were found to promote cell proliferation by increasing the intracellular activity of E2F transcription factors, despite the fact that miR-17, -20a, and -106b directly target the transcripts that encode for this protein family.Mir-17, -20a, and -106b downregulate a common set of pro- and anti-proliferative target genes to impact cell cycle progression of USSC and increase intracellular activity of E2F transcription factors to govern G(1)/S transition." @default.
• W2078210863 created "2016-06-24" @default.
• W2078210863 creator A5010196429 @default.
• W2078210863 creator A5016038480 @default.
• W2078210863 creator A5027878787 @default.
• W2078210863 creator A5040252316 @default.
• W2078210863 creator A5041930158 @default.
• W2078210863 creator A5042084987 @default.
• W2078210863 creator A5042253832 @default.
• W2078210863 creator A5046081514 @default.
• W2078210863 creator A5048771947 @default.
• W2078210863 date "2011-01-20" @default.
• W2078210863 modified "2023-09-26" @default.
• W2078210863 title "MicroRNAs MiR-17, MiR-20a, and MiR-106b Act in Concert to Modulate E2F Activity on Cell Cycle Arrest during Neuronal Lineage Differentiation of USSC" @default.
• W2078210863 cites W144423133 @default.
• W2078210863 cites W1845790496 @default.
• W2078210863 cites W1968463611 @default.
• W2078210863 cites W1968726212 @default.
• W2078210863 cites W1969003435 @default.
• W2078210863 cites W1973859136 @default.
• W2078210863 cites W1980269624 @default.
• W2078210863 cites W1982752738 @default.
• W2078210863 cites W1989617578 @default.
• W2078210863 cites W1991155290 @default.
• W2078210863 cites W1993799748 @default.
• W2078210863 cites W1995979905 @default.
• W2078210863 cites W2001627329 @default.
• W2078210863 cites W2006195578 @default.
• W2078210863 cites W2008797552 @default.
• W2078210863 cites W2014064723 @default.
• W2078210863 cites W2014613601 @default.
• W2078210863 cites W2015018301 @default.
• W2078210863 cites W2023121881 @default.
• W2078210863 cites W2026004604 @default.
• W2078210863 cites W2027862889 @default.
• W2078210863 cites W2031475327 @default.
• W2078210863 cites W2034800429 @default.
• W2078210863 cites W2035459770 @default.
• W2078210863 cites W2036534625 @default.
• W2078210863 cites W2040532363 @default.
• W2078210863 cites W2042027879 @default.
• W2078210863 cites W2044832480 @default.
• W2078210863 cites W2045423886 @default.
• W2078210863 cites W2045830695 @default.
• W2078210863 cites W2046486243 @default.
• W2078210863 cites W2046930479 @default.
• W2078210863 cites W2047119105 @default.
• W2078210863 cites W2050869737 @default.
• W2078210863 cites W2064557873 @default.
• W2078210863 cites W2066125587 @default.
• W2078210863 cites W2070479154 @default.
• W2078210863 cites W2071925802 @default.
• W2078210863 cites W2082213106 @default.
• W2078210863 cites W2083381199 @default.
• W2078210863 cites W2087056964 @default.
• W2078210863 cites W2087579173 @default.
• W2078210863 cites W2089218510 @default.
• W2078210863 cites W2090827556 @default.
• W2078210863 cites W2090936597 @default.
• W2078210863 cites W2094915354 @default.
• W2078210863 cites W2100975741 @default.
• W2078210863 cites W2101136715 @default.
• W2078210863 cites W2104682649 @default.
• W2078210863 cites W2106106046 @default.
• W2078210863 cites W2107635158 @default.
• W2078210863 cites W2108836814 @default.
• W2078210863 cites W2121619780 @default.
• W2078210863 cites W2121629705 @default.
• W2078210863 cites W2122683221 @default.
• W2078210863 cites W2125536613 @default.
• W2078210863 cites W2128559716 @default.
• W2078210863 cites W2135733051 @default.
• W2078210863 cites W2147164277 @default.
• W2078210863 cites W2161222316 @default.
• W2078210863 cites W2162674813 @default.
• W2078210863 cites W2168813512 @default.
• W2078210863 cites W2910065277 @default.
• W2078210863 doi "https://doi.org/10.1371/journal.pone.0016138" @default.
• W2078210863 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3024412" @default.
• W2078210863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21283765" @default.
• W2078210863 hasPublicationYear "2011" @default.
• W2078210863 type Work @default.
• W2078210863 sameAs 2078210863 @default.
• W2078210863 citedByCount "122" @default.
• W2078210863 countsByYear W20782108632012 @default.
• W2078210863 countsByYear W20782108632013 @default.
• W2078210863 countsByYear W20782108632014 @default.
• W2078210863 countsByYear W20782108632015 @default.
• W2078210863 countsByYear W20782108632016 @default.
• W2078210863 countsByYear W20782108632017 @default.
• W2078210863 countsByYear W20782108632018 @default.
• W2078210863 countsByYear W20782108632019 @default.
• W2078210863 countsByYear W20782108632020 @default.
• W2078210863 countsByYear W20782108632021 @default.
• W2078210863 countsByYear W20782108632022 @default.
• W2078210863 countsByYear W20782108632023 @default.
• W2078210863 crossrefType "journal-article" @default.
• W2078210863 hasAuthorship W2078210863A5010196429 @default.

• next