Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078214705> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2078214705 endingPage "A243" @default.
- W2078214705 startingPage "A243" @default.
- W2078214705 abstract "<h3>Introduction</h3> The prevalence of cirrhosis attributable to NAFLD is rising and an increase in NAFLD related HCC is anticipated. The authors have explored the pervasiveness of NAFLD in their own patients with HCC. <h3>Methods</h3> From 2003, all patients in North East UK have been referred to our tertiary centre and managed within a multidisciplinary environment according to the EASL guidelines. Age, underlying liver disease, stage at diagnosis (ChildPugh/OKUDA/CLIP/BCLC) have been documented prospectively, as have modes of detection and diagnosis, treatments and outcomes. <h3>Results</h3> This cohort includes 641 consecutive cases. Annual referrals increased fourfold during the study period and 10-fold compared to a cohort studied between 1995 and 2000. Presently, 16% have no evidence of underlying chronic liver disease, although features of the metabolic syndrome are common. This percentage has remained constant, reflecting an increase in actual numbers. In individuals with cirrhosis, NAFLD is now the commonest cause, accounting for 41%, versus ALD (30%); HCV/HBV (14%); PBC/autoimmune disease (7%); haemochromatosis (4%) and cryptogenic cirrhosis (4%). The age at presentation with HCC was significantly different between the aetiologies (71; 65 and 60 years for NAFLD, ALD and HCV respectively). In the last year, NAFLD HCC detected by surveillance has increased, but only accounted for 30% of cases (ALD 41%; HCV 75%). A third of NAFLD HCC were detected incidentally, while the remaining 40% presented symptomatically, with the diagnosis of NAFLD cirrhosis and HCC being made synchronously in individuals with a negative liver screen, little alcohol intake, with diagnostic clinical features of the metabolic syndrome and radiological and/or histological evidence of cirrhosis. Consequently, 43% of NAFLD HCC patients presented with BCLC stage D disease, compared to only 10–20% for other aetiologies. Survival reflecting the CLIP and BCLC staging systems was similar in the aetiological groups, regardless of the older age of NAFLD HCC patients. <h3>Conclusion</h3> The increasing prevalence of the metabolic syndrome is associated with an increase in HCC, in both cirrhotic and non-cirrhotic patients. Patients with NAFLD cirrhosis related HCC have a poorer outcome, reflecting the advanced stage of their disease at presentation, rather than their increased age or comorbidity. The study strategies for surveillance fail this escalating population." @default.
- W2078214705 created "2016-06-24" @default.
- W2078214705 creator A5005396872 @default.
- W2078214705 creator A5009151363 @default.
- W2078214705 creator A5013636353 @default.
- W2078214705 creator A5014535837 @default.
- W2078214705 creator A5018514950 @default.
- W2078214705 creator A5025310391 @default.
- W2078214705 creator A5036232241 @default.
- W2078214705 creator A5053756261 @default.
- W2078214705 creator A5067053021 @default.
- W2078214705 creator A5078227239 @default.
- W2078214705 date "2011-03-13" @default.
- W2078214705 modified "2023-09-27" @default.
- W2078214705 title "NAFLD and the changing face of hepatocellular cancer (HCC)" @default.
- W2078214705 doi "https://doi.org/10.1136/gut.2011.239301.515" @default.
- W2078214705 hasPublicationYear "2011" @default.
- W2078214705 type Work @default.
- W2078214705 sameAs 2078214705 @default.
- W2078214705 citedByCount "4" @default.
- W2078214705 countsByYear W20782147052012 @default.
- W2078214705 countsByYear W20782147052013 @default.
- W2078214705 countsByYear W20782147052015 @default.
- W2078214705 crossrefType "journal-article" @default.
- W2078214705 hasAuthorship W2078214705A5005396872 @default.
- W2078214705 hasAuthorship W2078214705A5009151363 @default.
- W2078214705 hasAuthorship W2078214705A5013636353 @default.
- W2078214705 hasAuthorship W2078214705A5014535837 @default.
- W2078214705 hasAuthorship W2078214705A5018514950 @default.
- W2078214705 hasAuthorship W2078214705A5025310391 @default.
- W2078214705 hasAuthorship W2078214705A5036232241 @default.
- W2078214705 hasAuthorship W2078214705A5053756261 @default.
- W2078214705 hasAuthorship W2078214705A5067053021 @default.
- W2078214705 hasAuthorship W2078214705A5078227239 @default.
- W2078214705 hasBestOaLocation W20782147051 @default.
- W2078214705 hasConcept C121608353 @default.
- W2078214705 hasConcept C126322002 @default.
- W2078214705 hasConcept C2776231280 @default.
- W2078214705 hasConcept C2777075537 @default.
- W2078214705 hasConcept C2777214474 @default.
- W2078214705 hasConcept C2778019345 @default.
- W2078214705 hasConcept C2778772119 @default.
- W2078214705 hasConcept C2779102576 @default.
- W2078214705 hasConcept C2779134260 @default.
- W2078214705 hasConcept C2780578515 @default.
- W2078214705 hasConcept C511355011 @default.
- W2078214705 hasConcept C71924100 @default.
- W2078214705 hasConcept C72563966 @default.
- W2078214705 hasConcept C90924648 @default.
- W2078214705 hasConceptScore W2078214705C121608353 @default.
- W2078214705 hasConceptScore W2078214705C126322002 @default.
- W2078214705 hasConceptScore W2078214705C2776231280 @default.
- W2078214705 hasConceptScore W2078214705C2777075537 @default.
- W2078214705 hasConceptScore W2078214705C2777214474 @default.
- W2078214705 hasConceptScore W2078214705C2778019345 @default.
- W2078214705 hasConceptScore W2078214705C2778772119 @default.
- W2078214705 hasConceptScore W2078214705C2779102576 @default.
- W2078214705 hasConceptScore W2078214705C2779134260 @default.
- W2078214705 hasConceptScore W2078214705C2780578515 @default.
- W2078214705 hasConceptScore W2078214705C511355011 @default.
- W2078214705 hasConceptScore W2078214705C71924100 @default.
- W2078214705 hasConceptScore W2078214705C72563966 @default.
- W2078214705 hasConceptScore W2078214705C90924648 @default.
- W2078214705 hasIssue "Suppl 1" @default.
- W2078214705 hasLocation W20782147051 @default.
- W2078214705 hasOpenAccess W2078214705 @default.
- W2078214705 hasPrimaryLocation W20782147051 @default.
- W2078214705 hasRelatedWork W2117763058 @default.
- W2078214705 hasRelatedWork W2126209504 @default.
- W2078214705 hasRelatedWork W2148441798 @default.
- W2078214705 hasRelatedWork W2329130836 @default.
- W2078214705 hasRelatedWork W2421241582 @default.
- W2078214705 hasRelatedWork W2770607349 @default.
- W2078214705 hasRelatedWork W29557401 @default.
- W2078214705 hasRelatedWork W3197598734 @default.
- W2078214705 hasRelatedWork W3200343841 @default.
- W2078214705 hasRelatedWork W4242883761 @default.
- W2078214705 hasVolume "60" @default.
- W2078214705 isParatext "false" @default.
- W2078214705 isRetracted "false" @default.
- W2078214705 magId "2078214705" @default.
- W2078214705 workType "article" @default.