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- W2078215912 abstract "A general approach to the synthesis of enantiomerically pure α-phenyl amino alcohols via the asymmetric reduction of α-phenyl haloalkyl ketones or α-phenyl aminoalkyl ketones with B-chlorodiisopinocampheylborane is described. Using this approach, an improved synthesis of a potential antipsychotic, α-(4-fluorophenyl)-4-(2-pyrimidinyl)-1-piperazinebutanol in ⩾98% ee, and the broncholdilator 1-(2-methoxy-2-phenethyl)-4-(3-hydroxy-3-phenylpropyl)piperazine (eprozinol) in ⩾99% ee is achieved. © 1995 Wiley-Liss, Inc." @default.
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- W2078215912 title "Chiral synthesis via organoboranes. 41. The utility ofB-chlorodiisopinocampheylborane for a general synthesis of enantiomerically pure drugs" @default.
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- W2078215912 doi "https://doi.org/10.1002/chir.530070209" @default.
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