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• W2078217557 abstract "Increasing evidence suggests that extracellular DNA plays a part in the pathogenesis of systemic lupus erythematosus (SLE) independently of the involvement of anti-DNA autoantibodies. In this Perspectives article, the authors discuss the findings that have led to this conclusion, and explore the new therapeutic avenues that this discovery has opened. Specifically, the interesting prospect of targeting treatments at the structural manipulation of extracellular DNA is introduced and the strategies for achieving this goal that have shown promise in animal studies are presented. Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs, with glomerulonephritis representing a frequent and serious manifestation. SLE is characterized by the presence of various autoantibodies, including anti-DNA antibodies that occur in approximately 70% of patients with SLE and which contribute to disease pathogenesis. Consequently, immunosuppressive therapies are applied in the treatment of SLE to reduce autoantibody levels. However, increasing evidence suggests that DNA—especially double-stranded DNA—constitutes an important pathogenic factor that is able to activate inflammatory responses by itself in autoimmune diseases. Therefore, modifying the structure of DNA to reduce its pathogenicity might be a more targeted approach for the treatment of SLE than immunosuppression. This article presents information in support of this strategy, and discusses the potential methods of DNA structure manipulation—in light of data obtained from mouse models of SLE—including topoisomerase I inhibition, administration of DNase I, or modification of histones using heparin or histone deacetylase inhibitors." @default.
• W2078217557 created "2016-06-24" @default.
• W2078217557 creator A5056220988 @default.
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• W2078217557 date "2011-10-18" @default.
• W2078217557 modified "2023-09-27" @default.
• W2078217557 title "Structural modification of DNA—a therapeutic option in SLE?" @default.
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• W2078217557 doi "https://doi.org/10.1038/nrrheum.2011.153" @default.
• W2078217557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4745409" @default.
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