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- W2078220428 abstract "Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of stages from simple steatosis to non-alcoholic steatohepatitis, which can progress to fibrosis, cirrhosis and, ultimately, hepatocellular carcinoma. Despite being one of the most common chronic liver diseases, NAFLD pathogenesis remains largely unknown. In this review, we discuss the key molecular mechanisms involved in NAFLD development and progression, focusing on the emerging role of microRNAs. NAFLD is intrinsically related to obesity and the metabolic syndrome. Changes in lipid metabolism increase free fatty acids in blood, which in turn induces peripheral insulin resistance and increases oxidative and endoplasmic reticulum stress. Although not yet considered in the diagnosis of NAFLD, recent reports also reinforce the crucial role of apoptosis in disease progression via activation of either death receptor or mitochondrial pathways and p53. In addition, the role of gut microbiota and the gut-liver axis has been recently associated with NAFLD. Finally, there is an accumulating and growing body of evidence supporting the role of microRNAs in NAFLD pathogenesis and progression, as well as hinting at their use as biomarkers or therapeutic tools. The ultimate goal is to review different molecular pathways that may underlie NAFLD pathogenesis in the hope of finding targets for new and efficient therapeutic interventions." @default.
- W2078220428 created "2016-06-24" @default.
- W2078220428 creator A5004169355 @default.
- W2078220428 creator A5037374117 @default.
- W2078220428 creator A5074043200 @default.
- W2078220428 creator A5082623940 @default.
- W2078220428 date "2014-04-28" @default.
- W2078220428 modified "2023-10-17" @default.
- W2078220428 title "Revisiting the metabolic syndrome and paving the way for microRNAs in non-alcoholic fatty liver disease" @default.
- W2078220428 cites W1485267747 @default.
- W2078220428 cites W1534360145 @default.
- W2078220428 cites W1546139069 @default.
- W2078220428 cites W1561785625 @default.
- W2078220428 cites W1571104432 @default.
- W2078220428 cites W1830033513 @default.
- W2078220428 cites W1939069213 @default.
- W2078220428 cites W1964346105 @default.
- W2078220428 cites W1965130745 @default.
- W2078220428 cites W1965893213 @default.
- W2078220428 cites W1967964480 @default.
- W2078220428 cites W1968940692 @default.
- W2078220428 cites W1972989638 @default.
- W2078220428 cites W1975400918 @default.
- W2078220428 cites W1977247288 @default.
- W2078220428 cites W1980867561 @default.
- W2078220428 cites W1980914602 @default.
- W2078220428 cites W1981098987 @default.
- W2078220428 cites W1982331387 @default.
- W2078220428 cites W1982738547 @default.
- W2078220428 cites W1984077928 @default.
- W2078220428 cites W1984468543 @default.
- W2078220428 cites W1986782449 @default.
- W2078220428 cites W1988039243 @default.
- W2078220428 cites W1989277040 @default.
- W2078220428 cites W1993909796 @default.
- W2078220428 cites W1995000970 @default.
- W2078220428 cites W1997317586 @default.
- W2078220428 cites W2001399725 @default.
- W2078220428 cites W2001927173 @default.
- W2078220428 cites W2002904154 @default.
- W2078220428 cites W2004082802 @default.
- W2078220428 cites W2004410133 @default.
- W2078220428 cites W2006041438 @default.
- W2078220428 cites W2006304210 @default.
- W2078220428 cites W2007078899 @default.
- W2078220428 cites W2010055639 @default.
- W2078220428 cites W2010220662 @default.
- W2078220428 cites W2010645035 @default.
- W2078220428 cites W2010978375 @default.
- W2078220428 cites W2011210301 @default.
- W2078220428 cites W2011605466 @default.
- W2078220428 cites W2013813851 @default.
- W2078220428 cites W2014887370 @default.
- W2078220428 cites W2016294119 @default.
- W2078220428 cites W2019900254 @default.
- W2078220428 cites W2020823261 @default.
- W2078220428 cites W2023572311 @default.
- W2078220428 cites W2023828775 @default.
- W2078220428 cites W2024206172 @default.
- W2078220428 cites W2025049635 @default.
- W2078220428 cites W2026585836 @default.
- W2078220428 cites W2029426792 @default.
- W2078220428 cites W2029863996 @default.
- W2078220428 cites W2030354790 @default.
- W2078220428 cites W2031045721 @default.
- W2078220428 cites W2032172473 @default.
- W2078220428 cites W2032696674 @default.
- W2078220428 cites W2033112320 @default.
- W2078220428 cites W2034212495 @default.
- W2078220428 cites W2035682260 @default.
- W2078220428 cites W2036047239 @default.
- W2078220428 cites W2038018821 @default.
- W2078220428 cites W2038153203 @default.
- W2078220428 cites W2042074642 @default.
- W2078220428 cites W2042981158 @default.
- W2078220428 cites W2043361950 @default.
- W2078220428 cites W2044446923 @default.
- W2078220428 cites W2047043150 @default.
- W2078220428 cites W2048091871 @default.
- W2078220428 cites W2048473455 @default.
- W2078220428 cites W2049978305 @default.
- W2078220428 cites W2051303794 @default.
- W2078220428 cites W2054504536 @default.
- W2078220428 cites W2055355179 @default.
- W2078220428 cites W2058899285 @default.
- W2078220428 cites W2061298432 @default.
- W2078220428 cites W2061662539 @default.
- W2078220428 cites W2061897505 @default.
- W2078220428 cites W2063820789 @default.
- W2078220428 cites W2065612971 @default.
- W2078220428 cites W2067582836 @default.
- W2078220428 cites W2067740038 @default.
- W2078220428 cites W2068173054 @default.
- W2078220428 cites W2068291606 @default.
- W2078220428 cites W2070053386 @default.
- W2078220428 cites W2075363951 @default.
- W2078220428 cites W2078176020 @default.
- W2078220428 cites W2080696342 @default.