FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078222415> ?p ?o ?g. }

• W2078222415 endingPage "28" @default.
• W2078222415 startingPage "23" @default.
• W2078222415 abstract "Objective: To test the hypothesis that the interaction between the brain-derived neurotrophic factor (BDNF) and dopamine receptor D2 (DRD2)/ANKK1 gene contributes to individual differences in alexithymia. The personality construct of alexithymia refers to difficulties in emotional self-regulation and contributes as a risk factor to several mental disorders. Alexithymic individuals show an impoverished conscious experience of emotions but an intact autonomic emotional response. Persons with high alexithymia scores reportedly show a reduced activation of the anterior cingulate cortex (ACC) during the processing of emotional stimuli. An interaction between two polymorphisms on the BDNF and DRD2/ANKK1 gene has been recently associated with reduced gray matter volume in the ACC and higher trait anxiety. Methods: We conducted a genetic association study. A total of 664 healthy participants completed the Toronto Alexithymia Scale questionnaire and were genotyped for the BDNF Val66Met (rs6265) and the DRD2/ANKK1 Taq IA (rs1800497) polymorphisms. Results: Carriers of at least one BDNF 66Met and one DRD2/ANKK1 A1 allele showed the highest scores in the total Toronto Alexithymia Scale and in the subscale “Difficulties Identifying Feelings.” Conclusion: In line with recent studies investigating the role of BDNF Val66Met and DRD2/ANKK1 Taq IA polymorphisms on anxiety and gray matter volume in the ACC, our findings provide the first evidence for a genetic contribution to alexithymia. ACC = anterior cingulate cortex; TAS-20 = Toronto Alexithymia Scale; DIF = TAS-20 subscale Difficulties Identifying Feelings; DDF = TAS-20 subscale Difficulties Describing Feelings; EOT = TAS-20 subscale Externally Oriented Thinking; BDNF = brain-derived neurotrophic factor; DRD2 = dopamine receptor D2; CBF = cerebral blood flow; TCI = Temperament and Character Inventory; VTA = ventral tegmental area; PD = panic disorder." @default.
• W2078222415 created "2016-06-24" @default.
• W2078222415 creator A5022713595 @default.
• W2078222415 creator A5042117336 @default.
• W2078222415 creator A5045017963 @default.
• W2078222415 creator A5048132181 @default.
• W2078222415 date "2011-01-01" @default.
• W2078222415 modified "2023-10-03" @default.
• W2078222415 title "Interaction Effect of Functional Variants of the BDNF and DRD2/ANKK1 Gene Is Associated With Alexithymia in Healthy Human Subjects" @default.
• W2078222415 cites W1553261973 @default.
• W2078222415 cites W1659760658 @default.
• W2078222415 cites W1965050550 @default.
• W2078222415 cites W1965222967 @default.
• W2078222415 cites W1966725992 @default.
• W2078222415 cites W1967075670 @default.
• W2078222415 cites W1967711154 @default.
• W2078222415 cites W1976347099 @default.
• W2078222415 cites W1983045607 @default.
• W2078222415 cites W1985058900 @default.
• W2078222415 cites W1989844817 @default.
• W2078222415 cites W1991640690 @default.
• W2078222415 cites W2003224343 @default.
• W2078222415 cites W2003490608 @default.
• W2078222415 cites W2006697950 @default.
• W2078222415 cites W2011649780 @default.
• W2078222415 cites W2014870330 @default.
• W2078222415 cites W2020993696 @default.
• W2078222415 cites W2022634896 @default.
• W2078222415 cites W2022659240 @default.
• W2078222415 cites W2022718201 @default.
• W2078222415 cites W2025311391 @default.
• W2078222415 cites W2025994528 @default.
• W2078222415 cites W2037457092 @default.
• W2078222415 cites W2049865797 @default.
• W2078222415 cites W2050042714 @default.
• W2078222415 cites W2050371496 @default.
• W2078222415 cites W2066412250 @default.
• W2078222415 cites W2068949066 @default.
• W2078222415 cites W2073895008 @default.
• W2078222415 cites W2075362165 @default.
• W2078222415 cites W2082872212 @default.
• W2078222415 cites W2086381132 @default.
• W2078222415 cites W2087459955 @default.
• W2078222415 cites W2089391141 @default.
• W2078222415 cites W2099218859 @default.
• W2078222415 cites W2100060883 @default.
• W2078222415 cites W2111038577 @default.
• W2078222415 cites W2125823313 @default.
• W2078222415 cites W2126701055 @default.
• W2078222415 cites W2129478806 @default.
• W2078222415 cites W2130417276 @default.
• W2078222415 cites W2133518193 @default.
• W2078222415 cites W2148116126 @default.
• W2078222415 cites W2154652565 @default.
• W2078222415 cites W2324724434 @default.
• W2078222415 cites W2328335652 @default.
• W2078222415 cites W2415974929 @default.
• W2078222415 cites W4376849761 @default.
• W2078222415 doi "https://doi.org/10.1097/psy.0b013e31820037c1" @default.
• W2078222415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21097659" @default.
• W2078222415 hasPublicationYear "2011" @default.
• W2078222415 type Work @default.
• W2078222415 sameAs 2078222415 @default.
• W2078222415 citedByCount "42" @default.
• W2078222415 countsByYear W20782224152012 @default.
• W2078222415 countsByYear W20782224152013 @default.
• W2078222415 countsByYear W20782224152014 @default.
• W2078222415 countsByYear W20782224152015 @default.
• W2078222415 countsByYear W20782224152016 @default.
• W2078222415 countsByYear W20782224152017 @default.
• W2078222415 countsByYear W20782224152018 @default.
• W2078222415 countsByYear W20782224152020 @default.
• W2078222415 countsByYear W20782224152021 @default.
• W2078222415 countsByYear W20782224152022 @default.
• W2078222415 crossrefType "journal-article" @default.
• W2078222415 hasAuthorship W2078222415A5022713595 @default.
• W2078222415 hasAuthorship W2078222415A5042117336 @default.
• W2078222415 hasAuthorship W2078222415A5045017963 @default.
• W2078222415 hasAuthorship W2078222415A5048132181 @default.
• W2078222415 hasConcept C118552586 @default.
• W2078222415 hasConcept C126322002 @default.
• W2078222415 hasConcept C15744967 @default.
• W2078222415 hasConcept C160539049 @default.
• W2078222415 hasConcept C169760540 @default.
• W2078222415 hasConcept C169900460 @default.
• W2078222415 hasConcept C170493617 @default.
• W2078222415 hasConcept C2778402161 @default.
• W2078222415 hasConcept C2778468875 @default.
• W2078222415 hasConcept C2778790584 @default.
• W2078222415 hasConcept C2780559815 @default.
• W2078222415 hasConcept C2781210436 @default.
• W2078222415 hasConcept C529278444 @default.
• W2078222415 hasConcept C558461103 @default.
• W2078222415 hasConcept C70410870 @default.
• W2078222415 hasConcept C71924100 @default.
• W2078222415 hasConceptScore W2078222415C118552586 @default.
• W2078222415 hasConceptScore W2078222415C126322002 @default.
• W2078222415 hasConceptScore W2078222415C15744967 @default.

• next