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- W2078225503 abstract "Lymphocytes must proliferate and differentiate in response to low concentrations of a vast array of antigens. The requirements of broad specificity and sensitivity conflict because the former is met by low-affinity antigen receptors, which precludes achieving the latter with high-affinity receptors. Coligation of the membrane protein CD19 with the antigen receptor of B lymphocytes decreased the threshold for antigen receptor-dependent stimulation by two orders of magnitude. B lymphocytes proliferated when approximately 100 antigen receptors per cell, 0.03 percent of the total, were coligated with CD19. The B cell resolves its dilemma by having an accessory protein that enables activation when few antigen receptors are occupied." @default.
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- W2078225503 date "1992-04-03" @default.
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- W2078225503 title "CD19: Lowering the Threshold for Antigen Receptor Stimulation of B Lymphocytes" @default.
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- W2078225503 doi "https://doi.org/10.1126/science.1373518" @default.
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