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• W2078230553 abstract "The influence of single nucleotide polymorphisms (SNP) of the FTO gene has been shown to change over time. The aim was to investigate the relationship between a SNP of the FTO gene (rs9939609) and obesity-related characteristics longitudinally during childhood and puberty. From 101 children (58 boys and 43 girls), the FTO (rs9939609) genotype and yearly anthropometric data from birth to age 7 yr were determined. From ages 12 to 17 yr, we measured anthropometry, body composition, leptin concentrations, physical activity, hours watching television, and attitude toward eating yearly; parental characteristics were determined as well. At age 17 yr, 20% of the children were overweight/obese, and 88% of the overweight/obese children had the A allele in contrast to 45% of the lean children (P < 0.001). The A allele carriers had a higher fat mass index (kilograms per square meter) and higher leptin concentrations (micrograms per liter) during puberty, except at age 14 yr. Multiple regression analyses with body mass index (BMI; kilograms per square meter) as the dependent variable showed that at ages 12 and 17 yr, dietary restraint score, disinhibition score, BMI of the mother, and the FTO A allele significantly contributed to the model (R2 = 0.29, P < 0.002; and R2 = 0.39, P < 0.001). At age 14 yr, dietary restraint score, disinhibition score, and leptin concentrations per kilogram of fat mass significantly contributed to the model (R2 = 0.25; P < 0.02). The FTO A allele (rs9939609) is associated with higher BMI, fat mass index, and leptin concentrations from the age of 12 yr, whereas the associations show a dip at ages 13–14 yr and become stronger at age 17 yr. The dip is presumably caused by the dominating endocrinological changes at midpuberty." @default.
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• W2078230553 date "2011-06-01" @default.
• W2078230553 modified "2023-10-17" @default.
• W2078230553 title "Associations between a Single Nucleotide Polymorphism of the<i>FTO</i>Gene (rs9939609) and Obesity-Related Characteristics over Time during Puberty in a Dutch Children Cohort" @default.
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• W2078230553 doi "https://doi.org/10.1210/jc.2010-2413" @default.
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