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- W2078235526 abstract "A mutagenicity test was conducted for 1,4-pentadiene-3-ol, 2,4-hexadiene, isoprene, cis- and trans-piperylene in the bacterial mutation assay using Salmonella typhimurium (S. typhimurium) strain TA 100, TA98, TA1535 and Escherichia coli (E. coli) WP2uvrA/pKM101 with and without metabolic activation by S9 mix in the preincubation method. The mutagenicity of 1,3-butadiene was tested by the gas exposure method. Mutagenicity was weakly positive for 1,4-pentadiene-3-ol in TA 100 with S9 mix and was pseudopositive for WP2uvrA/pKM101 without S9 mix. Mutagenicity was very clear for 1,3-butadiene in 10 fold concentrated TA1535 with S9 mix. The 2,4-hexadiene, isoprene, cis-piperlylene and trans-piperlylene were not mutagenic on S. typhimurium TA98, TA100, TA1535 or E. coli WP2uvrA/pKM101 with or without metabolic activation. It can be concluded from these results, that chemicals, containing double bond carbon (C=C) chemical generally tend to show weak mutagenicity in the presence of the metabolic activation system." @default.
- W2078235526 created "2016-06-24" @default.
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- W2078235526 date "2002-01-01" @default.
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- W2078235526 title "MutagenicityTesting of 1,3-Butadiene, 1,4-Pentadiene-3-ol, Isoprene, 2,4-Hexadiene, cis- and trans-Piperlylene." @default.
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- W2078235526 doi "https://doi.org/10.1248/jhs.48.73" @default.
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