FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078237849> ?p ?o ?g. }

• W2078237849 endingPage "821" @default.
• W2078237849 startingPage "806" @default.
• W2078237849 abstract "Background: Adipose-derived stromal cells are a potential cell source for the successful healing of skeletal defects. In this study, the authors sought to investigate the potential for cranial suture-derived mesenchymal cells to promote the osteogenic differentiation of adipose-derived stromal cells. Various reports have previously examined the unique in vitro attributes of suture-derived mesenchymal cells; this study sought to extend those findings. Methods: Suture-derived mesenchymal cells were isolated from wild-type mice (n = 30) from both fusing posterofrontal and patent sagittal sutures. Cells were placed in Transwell inserts with human adipose-derived stromal cells (n = 5 patients) with osteogenic differentiation medium with or without recombinant Noggin (10 to 400 ng/ml). Specific gene expression of osteogenic markers and Hedgehog pathway were assayed; standard osteogenic assays (alkaline phosphatase and alizarin red staining) were performed. All assays were performed in triplicate. Results: Both posterofrontal and sagittal suture-derived mesenchymal cells induced osteogenic differentiation of adipose-derived stromal cells (p < 0.05). Posterofrontal suture-derived mesenchymal cells induced adipose-derived stromal cell osteogenesis to a greater degree than sagittal suture-derived mesenchymal cells (p < 0.05). This was accompanied by an increase in bone morphogenetic protein expression (p < 0.05). Finally, recombinant Noggin mitigated the pro-osteogenic effects of co-culture accompanied by a reduction in Hedgehog signaling (p < 0.05). Conclusions: Suture-derived mesenchymal cells secrete paracrine factors that induce osteogenic differentiation of multipotent stromal cells (human adipose-derived stromal cells). Cells derived from the fusing posterofrontal suture do this to a significantly greater degree than cells from the patent sagittal suture. Enhanced bone morphogenetic protein and Hedgehog signaling may underlie this paracrine effect." @default.
• W2078237849 created "2016-06-24" @default.
• W2078237849 creator A5005728573 @default.
• W2078237849 creator A5029107105 @default.
• W2078237849 creator A5063708863 @default.
• W2078237849 creator A5064932750 @default.
• W2078237849 creator A5080524079 @default.
• W2078237849 date "2010-09-01" @default.
• W2078237849 modified "2023-09-26" @default.
• W2078237849 title "Paracrine Interaction between Adipose-Derived Stromal Cells and Cranial Suture–Derived Mesenchymal Cells" @default.
• W2078237849 cites W1575237019 @default.
• W2078237849 cites W1833613269 @default.
• W2078237849 cites W1944656442 @default.
• W2078237849 cites W1964433813 @default.
• W2078237849 cites W1967341011 @default.
• W2078237849 cites W1968319798 @default.
• W2078237849 cites W1968816076 @default.
• W2078237849 cites W1973725021 @default.
• W2078237849 cites W1974199463 @default.
• W2078237849 cites W1980955678 @default.
• W2078237849 cites W1985648712 @default.
• W2078237849 cites W1985952359 @default.
• W2078237849 cites W1986763776 @default.
• W2078237849 cites W1993722891 @default.
• W2078237849 cites W2009773280 @default.
• W2078237849 cites W2011726646 @default.
• W2078237849 cites W2012330620 @default.
• W2078237849 cites W2013839360 @default.
• W2078237849 cites W2025682321 @default.
• W2078237849 cites W2026120252 @default.
• W2078237849 cites W2026286469 @default.
• W2078237849 cites W2032101629 @default.
• W2078237849 cites W2032441881 @default.
• W2078237849 cites W2036491313 @default.
• W2078237849 cites W2039653901 @default.
• W2078237849 cites W2044819141 @default.
• W2078237849 cites W2046409391 @default.
• W2078237849 cites W2051428145 @default.
• W2078237849 cites W2052470498 @default.
• W2078237849 cites W2053307967 @default.
• W2078237849 cites W2054867248 @default.
• W2078237849 cites W2060229972 @default.
• W2078237849 cites W2069119535 @default.
• W2078237849 cites W2075010531 @default.
• W2078237849 cites W2076857416 @default.
• W2078237849 cites W2080135499 @default.
• W2078237849 cites W2080904393 @default.
• W2078237849 cites W2083838222 @default.
• W2078237849 cites W2085588582 @default.
• W2078237849 cites W2086260905 @default.
• W2078237849 cites W2087094815 @default.
• W2078237849 cites W2087472570 @default.
• W2078237849 cites W2093985074 @default.
• W2078237849 cites W2094329940 @default.
• W2078237849 cites W2095244767 @default.
• W2078237849 cites W2101431584 @default.
• W2078237849 cites W2107503723 @default.
• W2078237849 cites W2110341920 @default.
• W2078237849 cites W2111636386 @default.
• W2078237849 cites W2121880251 @default.
• W2078237849 cites W2137256580 @default.
• W2078237849 cites W2155343233 @default.
• W2078237849 cites W2166661372 @default.
• W2078237849 cites W2167927701 @default.
• W2078237849 cites W2169422563 @default.
• W2078237849 cites W2171002939 @default.
• W2078237849 cites W2967206079 @default.
• W2078237849 cites W2986759608 @default.
• W2078237849 cites W4256003489 @default.
• W2078237849 doi "https://doi.org/10.1097/prs.0b013e3181e5f81a" @default.
• W2078237849 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2933932" @default.
• W2078237849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20811214" @default.
• W2078237849 hasPublicationYear "2010" @default.
• W2078237849 type Work @default.
• W2078237849 sameAs 2078237849 @default.
• W2078237849 citedByCount "14" @default.
• W2078237849 countsByYear W20782378492012 @default.
• W2078237849 countsByYear W20782378492013 @default.
• W2078237849 countsByYear W20782378492014 @default.
• W2078237849 countsByYear W20782378492016 @default.
• W2078237849 countsByYear W20782378492017 @default.
• W2078237849 countsByYear W20782378492019 @default.
• W2078237849 countsByYear W20782378492021 @default.
• W2078237849 countsByYear W20782378492022 @default.
• W2078237849 countsByYear W20782378492023 @default.
• W2078237849 crossrefType "journal-article" @default.
• W2078237849 hasAuthorship W2078237849A5005728573 @default.
• W2078237849 hasAuthorship W2078237849A5029107105 @default.
• W2078237849 hasAuthorship W2078237849A5063708863 @default.
• W2078237849 hasAuthorship W2078237849A5064932750 @default.
• W2078237849 hasAuthorship W2078237849A5080524079 @default.
• W2078237849 hasBestOaLocation W20782378492 @default.
• W2078237849 hasConcept C104317684 @default.
• W2078237849 hasConcept C126322002 @default.
• W2078237849 hasConcept C142724271 @default.
• W2078237849 hasConcept C16930146 @default.
• W2078237849 hasConcept C170493617 @default.
• W2078237849 hasConcept C171089720 @default.

• next