Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078238215> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2078238215 endingPage "174" @default.
- W2078238215 startingPage "170" @default.
- W2078238215 abstract "G-protein coupled receptors (GPCRs) are found to be attractive drug targets for the treatment of various neuronal diseases. Allosteric modulators have their role in enhancing or suppressing the effect of glutamate on mGluRs. Structure of mGluR1 was generated with the help of Modeller software by considering human B2-adrenergic GPCR protein as template. Structure of various already known drug molecules were used for similarity search in the ZINC database and a large number of similar molecules were obtained, than filtering of these molecules were done by applying drug features. Molecules were screened by Molegro Virtual Docking program and numbers of novel molecules were generated by using LigBuilder software. Finally 16 novel drug candidates were selected, which were showing better results than the seed molecule and previously known modulators. These results will help in designing and synthesis of better drugs against diseases like Epilepsy and Parkinson's." @default.
- W2078238215 created "2016-06-24" @default.
- W2078238215 creator A5024667263 @default.
- W2078238215 creator A5028163065 @default.
- W2078238215 date "2012-02-28" @default.
- W2078238215 modified "2023-10-18" @default.
- W2078238215 title "Designing allosteric modulators for active conformational state of m-glutamate G-protein coupled receptors" @default.
- W2078238215 cites W1992790614 @default.
- W2078238215 cites W2001311316 @default.
- W2078238215 cites W2066142272 @default.
- W2078238215 cites W2126987855 @default.
- W2078238215 doi "https://doi.org/10.6026/97320630008170" @default.
- W2078238215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3301996" @default.
- W2078238215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22419835" @default.
- W2078238215 hasPublicationYear "2012" @default.
- W2078238215 type Work @default.
- W2078238215 sameAs 2078238215 @default.
- W2078238215 citedByCount "3" @default.
- W2078238215 countsByYear W20782382152015 @default.
- W2078238215 countsByYear W20782382152017 @default.
- W2078238215 countsByYear W20782382152019 @default.
- W2078238215 crossrefType "journal-article" @default.
- W2078238215 hasAuthorship W2078238215A5024667263 @default.
- W2078238215 hasAuthorship W2078238215A5028163065 @default.
- W2078238215 hasBestOaLocation W20782382151 @default.
- W2078238215 hasConcept C103697762 @default.
- W2078238215 hasConcept C135285700 @default.
- W2078238215 hasConcept C159110408 @default.
- W2078238215 hasConcept C166342909 @default.
- W2078238215 hasConcept C169627665 @default.
- W2078238215 hasConcept C170493617 @default.
- W2078238215 hasConcept C181199279 @default.
- W2078238215 hasConcept C185592680 @default.
- W2078238215 hasConcept C193153401 @default.
- W2078238215 hasConcept C207951395 @default.
- W2078238215 hasConcept C2776038425 @default.
- W2078238215 hasConcept C41008148 @default.
- W2078238215 hasConcept C41685203 @default.
- W2078238215 hasConcept C49051014 @default.
- W2078238215 hasConcept C55493867 @default.
- W2078238215 hasConcept C60644358 @default.
- W2078238215 hasConcept C61174792 @default.
- W2078238215 hasConcept C70721500 @default.
- W2078238215 hasConcept C71924100 @default.
- W2078238215 hasConcept C74187038 @default.
- W2078238215 hasConcept C86803240 @default.
- W2078238215 hasConceptScore W2078238215C103697762 @default.
- W2078238215 hasConceptScore W2078238215C135285700 @default.
- W2078238215 hasConceptScore W2078238215C159110408 @default.
- W2078238215 hasConceptScore W2078238215C166342909 @default.
- W2078238215 hasConceptScore W2078238215C169627665 @default.
- W2078238215 hasConceptScore W2078238215C170493617 @default.
- W2078238215 hasConceptScore W2078238215C181199279 @default.
- W2078238215 hasConceptScore W2078238215C185592680 @default.
- W2078238215 hasConceptScore W2078238215C193153401 @default.
- W2078238215 hasConceptScore W2078238215C207951395 @default.
- W2078238215 hasConceptScore W2078238215C2776038425 @default.
- W2078238215 hasConceptScore W2078238215C41008148 @default.
- W2078238215 hasConceptScore W2078238215C41685203 @default.
- W2078238215 hasConceptScore W2078238215C49051014 @default.
- W2078238215 hasConceptScore W2078238215C55493867 @default.
- W2078238215 hasConceptScore W2078238215C60644358 @default.
- W2078238215 hasConceptScore W2078238215C61174792 @default.
- W2078238215 hasConceptScore W2078238215C70721500 @default.
- W2078238215 hasConceptScore W2078238215C71924100 @default.
- W2078238215 hasConceptScore W2078238215C74187038 @default.
- W2078238215 hasConceptScore W2078238215C86803240 @default.
- W2078238215 hasIssue "4" @default.
- W2078238215 hasLocation W20782382151 @default.
- W2078238215 hasLocation W20782382152 @default.
- W2078238215 hasLocation W20782382153 @default.
- W2078238215 hasLocation W20782382154 @default.
- W2078238215 hasOpenAccess W2078238215 @default.
- W2078238215 hasPrimaryLocation W20782382151 @default.
- W2078238215 hasRelatedWork W2058431385 @default.
- W2078238215 hasRelatedWork W2062248967 @default.
- W2078238215 hasRelatedWork W2078238215 @default.
- W2078238215 hasRelatedWork W2123563726 @default.
- W2078238215 hasRelatedWork W2145283218 @default.
- W2078238215 hasRelatedWork W2168561710 @default.
- W2078238215 hasRelatedWork W2274383865 @default.
- W2078238215 hasRelatedWork W2885109335 @default.
- W2078238215 hasRelatedWork W2973699061 @default.
- W2078238215 hasRelatedWork W4200127861 @default.
- W2078238215 hasVolume "8" @default.
- W2078238215 isParatext "false" @default.
- W2078238215 isRetracted "false" @default.
- W2078238215 magId "2078238215" @default.
- W2078238215 workType "article" @default.