FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078238416> ?p ?o ?g. }

• W2078238416 endingPage "761" @default.
• W2078238416 startingPage "750" @default.
• W2078238416 abstract "To investigate the effects of the microstructure of collagenous carriers on the in vivo function of bone sialoprotein (BSP) in mineralization and osteoblast differentiation, we examined the ultrastructure of reconstituted type I collagen (collagen) and heat-denatured collagen (gelatin) and the in vivo responses to purified bone-derived BSP that was implanted with collagen or gelatin into surgically created 8-mm rat calvarial bone defects. Scanning and transmission electron microscopies revealed that the collagen displayed a fine fibrillar structure with interconnecting spaces between the fibrils/fibers, while the gelatin completely lost this unique three-dimensional structure after denaturation. The rates of in vivo release of BSP from the collagen scaffold were significantly lower than those from the gelatin. Collagen-BSP, but not gelatin-BSP, induced early mineral deposition in the matrix of proliferating repair cells in the calvarial defects at approximately 4-7 days after implantation. Expression levels of osteoblast markers, alkaline phosphatase activity and amounts of new bone synthesized in the collagen-BSP treated defects were significantly greater than that in the gelatin-BSP treated defects (p<0.001). The data suggest that the fibrillar microstructure of reconstituted collagen is essential for retaining BSP at a higher concentration within the defects, which enhances BSP-mediated matrix mineralization and osteoblast differentiation during the repair of rat calvarial defects." @default.
• W2078238416 created "2016-06-24" @default.
• W2078238416 creator A5037691660 @default.
• W2078238416 creator A5055139463 @default.
• W2078238416 creator A5071760661 @default.
• W2078238416 creator A5089865739 @default.
• W2078238416 date "2007-02-01" @default.
• W2078238416 modified "2023-10-02" @default.
• W2078238416 title "Role of fibrillar structure of collagenous carrier in bone sialoprotein-mediated matrix mineralization and osteoblast differentiation" @default.
• W2078238416 cites W1493047535 @default.
• W2078238416 cites W1541935925 @default.
• W2078238416 cites W1565263903 @default.
• W2078238416 cites W1586020992 @default.
• W2078238416 cites W1963491783 @default.
• W2078238416 cites W1967470081 @default.
• W2078238416 cites W1971908037 @default.
• W2078238416 cites W1976876261 @default.
• W2078238416 cites W1977680000 @default.
• W2078238416 cites W1982903768 @default.
• W2078238416 cites W1984434232 @default.
• W2078238416 cites W1985261798 @default.
• W2078238416 cites W1986598651 @default.
• W2078238416 cites W1987431004 @default.
• W2078238416 cites W1988464853 @default.
• W2078238416 cites W1991842246 @default.
• W2078238416 cites W1996394089 @default.
• W2078238416 cites W1999741862 @default.
• W2078238416 cites W2008112661 @default.
• W2078238416 cites W2013613206 @default.
• W2078238416 cites W2027097734 @default.
• W2078238416 cites W2029628901 @default.
• W2078238416 cites W2037761234 @default.
• W2078238416 cites W2039705722 @default.
• W2078238416 cites W2039825182 @default.
• W2078238416 cites W2049616107 @default.
• W2078238416 cites W2050620674 @default.
• W2078238416 cites W2051849197 @default.
• W2078238416 cites W2053889214 @default.
• W2078238416 cites W2054615339 @default.
• W2078238416 cites W2054851376 @default.
• W2078238416 cites W2078137073 @default.
• W2078238416 cites W2088304666 @default.
• W2078238416 cites W2101889508 @default.
• W2078238416 cites W2107277218 @default.
• W2078238416 cites W2127578362 @default.
• W2078238416 cites W2129082054 @default.
• W2078238416 cites W2131230561 @default.
• W2078238416 cites W2165044415 @default.
• W2078238416 cites W2232407802 @default.
• W2078238416 doi "https://doi.org/10.1016/j.biomaterials.2006.09.022" @default.
• W2078238416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17045334" @default.
• W2078238416 hasPublicationYear "2007" @default.
• W2078238416 type Work @default.
• W2078238416 sameAs 2078238416 @default.
• W2078238416 citedByCount "54" @default.
• W2078238416 countsByYear W20782384162013 @default.
• W2078238416 countsByYear W20782384162014 @default.
• W2078238416 countsByYear W20782384162015 @default.
• W2078238416 countsByYear W20782384162016 @default.
• W2078238416 countsByYear W20782384162017 @default.
• W2078238416 countsByYear W20782384162018 @default.
• W2078238416 countsByYear W20782384162019 @default.
• W2078238416 countsByYear W20782384162020 @default.
• W2078238416 countsByYear W20782384162021 @default.
• W2078238416 countsByYear W20782384162022 @default.
• W2078238416 countsByYear W20782384162023 @default.
• W2078238416 crossrefType "journal-article" @default.
• W2078238416 hasAuthorship W2078238416A5037691660 @default.
• W2078238416 hasAuthorship W2078238416A5055139463 @default.
• W2078238416 hasAuthorship W2078238416A5071760661 @default.
• W2078238416 hasAuthorship W2078238416A5089865739 @default.
• W2078238416 hasConcept C106487976 @default.
• W2078238416 hasConcept C111696902 @default.
• W2078238416 hasConcept C12554922 @default.
• W2078238416 hasConcept C131075544 @default.
• W2078238416 hasConcept C134018914 @default.
• W2078238416 hasConcept C159985019 @default.
• W2078238416 hasConcept C160160445 @default.
• W2078238416 hasConcept C178790620 @default.
• W2078238416 hasConcept C181199279 @default.
• W2078238416 hasConcept C185592680 @default.
• W2078238416 hasConcept C189165786 @default.
• W2078238416 hasConcept C192562407 @default.
• W2078238416 hasConcept C202751555 @default.
• W2078238416 hasConcept C2776432469 @default.
• W2078238416 hasConcept C2778260815 @default.
• W2078238416 hasConcept C2778823387 @default.
• W2078238416 hasConcept C2780644872 @default.
• W2078238416 hasConcept C537208039 @default.
• W2078238416 hasConcept C55493867 @default.
• W2078238416 hasConcept C86803240 @default.
• W2078238416 hasConcept C95444343 @default.
• W2078238416 hasConceptScore W2078238416C106487976 @default.
• W2078238416 hasConceptScore W2078238416C111696902 @default.
• W2078238416 hasConceptScore W2078238416C12554922 @default.
• W2078238416 hasConceptScore W2078238416C131075544 @default.
• W2078238416 hasConceptScore W2078238416C134018914 @default.
• W2078238416 hasConceptScore W2078238416C159985019 @default.

• next