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• W2078242847 abstract "Brain aging is associated with synaptic decline and synaptic function is highly dependent on mitochondria. Increased levels of oxidative DNA base damage and accumulation of mitochondrial DNA (mtDNA) mutations or deletions lead to mitochondrial dysfunction, playing an important role in the aging process and the pathogenesis of several neurodegenerative diseases. Here we have investigated the repair of oxidative base damage, in synaptosomes of mouse brain during normal aging and in an AD model. During normal aging, a reduction in the base excision repair (BER) capacity was observed in the synaptosomal fraction, which was associated with a decrease in the level of BER proteins. However, we did not observe changes between the synaptosomal BER activities of presymptomatic and symptomatic AD mice harboring mutated amyolid precursor protein (APP), Tau, and presinilin-1 (PS1) (3xTgAD). Our findings suggest that the age-related reduction in BER capacity in the synaptosomal fraction might contribute to mitochondrial and synaptic dysfunction during aging. The development of AD-like pathology in the 3xTgAD mouse model was, however, not associated with deficiencies of the BER mechanisms in the synaptosomal fraction when the whole brain was analyzed." @default.
• W2078242847 created "2016-06-24" @default.
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• W2078242847 date "2012-04-01" @default.
• W2078242847 modified "2023-10-03" @default.
• W2078242847 title "Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer's disease" @default.
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• W2078242847 doi "https://doi.org/10.1016/j.neurobiolaging.2010.06.019" @default.
• W2078242847 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3041866" @default.
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• W2078242847 hasPublicationYear "2012" @default.
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