FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078244175> ?p ?o ?g. }

• W2078244175 endingPage "2512" @default.
• W2078244175 startingPage "2497" @default.
• W2078244175 abstract "Homocysteine (Hcy), an intermediate in methionine metabolism, has been proposed to be involved in hepatic fibrogenesis. Impaired liver function can alter Hcy metabolism. The aim of the present study was to determine plasma Hcy alterations in acute obstructive cholestasis and the subsequent biliary cirrhosis. Cholestasis was induced by bile duct ligation and sham-operated and unoperated rats were used as controls. The animals were studied on the days 7th, 14th, 21st and 28th after the operation. Plasma Hcy, cysteine, methionine, nitric oxide (NO) and liver S-adenosyl-methionine (SAM), S-adenosyl-homocysteine (SAH), SAM to SAH ratio and glutathione were measured. Chronic L-NAME treatment was also included in the study. Plasma Hcy concentrations were transiently elevated by the day 14th after bile duct ligation (P < 0.01) and subsequently returned to control levels. Similar relative fluctuations in plasma Hcy were observed in BDL rats after intraperitoneal methionine overload. Plasma methionine, cysteine and nitrite and nitrate were significantly increased after bile duct ligation. SAM to SAH ratio was diminished by the 1st week of cholestasis and remained significantly decreased throughout the study. These events were accompanied by a decrease in GSH to GSSG ratio in the liver. Chronic L-NAME treatment improved SAM to SAH ratio and prevented the elevation of plasma Hcy and methionine (P < 0.05) while couldn't influence the other parameters. In conclusion, this study demonstrates alterations in plasma Hcy and liver SAM and SAH contents in precirrhotic stages and in secondary biliary cirrhosis, for the first time. In addition, we observed that plasma Hcy concentrations in BDL rats follow a distinct pattern of alteration from what has been previously reported in other models of cirrhosis. NO overproduction may contribute to plasma Hcy elevation and liver SAM depletion after cholestasis." @default.
• W2078244175 created "2016-06-24" @default.
• W2078244175 creator A5006462762 @default.
• W2078244175 creator A5007554613 @default.
• W2078244175 creator A5023342808 @default.
• W2078244175 creator A5026902416 @default.
• W2078244175 creator A5028774736 @default.
• W2078244175 creator A5034729928 @default.
• W2078244175 creator A5039148668 @default.
• W2078244175 creator A5047959063 @default.
• W2078244175 creator A5057676863 @default.
• W2078244175 creator A5072254416 @default.
• W2078244175 creator A5078388565 @default.
• W2078244175 creator A5081866388 @default.
• W2078244175 date "2005-04-01" @default.
• W2078244175 modified "2023-10-11" @default.
• W2078244175 title "Homocysteine alterations in experimental cholestasis and its subsequent cirrhosis" @default.
• W2078244175 cites W1549590649 @default.
• W2078244175 cites W1574022706 @default.
• W2078244175 cites W1577459729 @default.
• W2078244175 cites W1775749144 @default.
• W2078244175 cites W1834223873 @default.
• W2078244175 cites W1925985333 @default.
• W2078244175 cites W1965026439 @default.
• W2078244175 cites W1972726157 @default.
• W2078244175 cites W1976981858 @default.
• W2078244175 cites W1977799375 @default.
• W2078244175 cites W1978884036 @default.
• W2078244175 cites W1984135951 @default.
• W2078244175 cites W1995014459 @default.
• W2078244175 cites W1997596609 @default.
• W2078244175 cites W2011312164 @default.
• W2078244175 cites W2014030487 @default.
• W2078244175 cites W2017564694 @default.
• W2078244175 cites W2018404966 @default.
• W2078244175 cites W2018534883 @default.
• W2078244175 cites W2018756843 @default.
• W2078244175 cites W2026261400 @default.
• W2078244175 cites W2028903190 @default.
• W2078244175 cites W2030350783 @default.
• W2078244175 cites W2031701136 @default.
• W2078244175 cites W2045083311 @default.
• W2078244175 cites W2054534199 @default.
• W2078244175 cites W2054790478 @default.
• W2078244175 cites W2057309352 @default.
• W2078244175 cites W2062440171 @default.
• W2078244175 cites W2063137402 @default.
• W2078244175 cites W2063228537 @default.
• W2078244175 cites W2064397023 @default.
• W2078244175 cites W2066696233 @default.
• W2078244175 cites W2067106162 @default.
• W2078244175 cites W2074884064 @default.
• W2078244175 cites W2078410199 @default.
• W2078244175 cites W2091031954 @default.
• W2078244175 cites W2092945190 @default.
• W2078244175 cites W2094364154 @default.
• W2078244175 cites W2111551037 @default.
• W2078244175 cites W2136535665 @default.
• W2078244175 cites W2136561166 @default.
• W2078244175 cites W2142731081 @default.
• W2078244175 cites W2150919423 @default.
• W2078244175 cites W2155203442 @default.
• W2078244175 cites W2159007804 @default.
• W2078244175 cites W4233783551 @default.
• W2078244175 cites W4253951442 @default.
• W2078244175 doi "https://doi.org/10.1016/j.lfs.2004.12.009" @default.
• W2078244175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15763080" @default.
• W2078244175 hasPublicationYear "2005" @default.
• W2078244175 type Work @default.
• W2078244175 sameAs 2078244175 @default.
• W2078244175 citedByCount "14" @default.
• W2078244175 countsByYear W20782441752013 @default.
• W2078244175 countsByYear W20782441752015 @default.
• W2078244175 countsByYear W20782441752016 @default.
• W2078244175 countsByYear W20782441752017 @default.
• W2078244175 countsByYear W20782441752019 @default.
• W2078244175 countsByYear W20782441752021 @default.
• W2078244175 crossrefType "journal-article" @default.
• W2078244175 hasAuthorship W2078244175A5006462762 @default.
• W2078244175 hasAuthorship W2078244175A5007554613 @default.
• W2078244175 hasAuthorship W2078244175A5023342808 @default.
• W2078244175 hasAuthorship W2078244175A5026902416 @default.
• W2078244175 hasAuthorship W2078244175A5028774736 @default.
• W2078244175 hasAuthorship W2078244175A5034729928 @default.
• W2078244175 hasAuthorship W2078244175A5039148668 @default.
• W2078244175 hasAuthorship W2078244175A5047959063 @default.
• W2078244175 hasAuthorship W2078244175A5057676863 @default.
• W2078244175 hasAuthorship W2078244175A5072254416 @default.
• W2078244175 hasAuthorship W2078244175A5078388565 @default.
• W2078244175 hasAuthorship W2078244175A5081866388 @default.
• W2078244175 hasConcept C126322002 @default.
• W2078244175 hasConcept C134018914 @default.
• W2078244175 hasConcept C181199279 @default.
• W2078244175 hasConcept C185592680 @default.
• W2078244175 hasConcept C2777090595 @default.
• W2078244175 hasConcept C2777214474 @default.
• W2078244175 hasConcept C2778593092 @default.
• W2078244175 hasConcept C2779201268 @default.

• next