Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078245510> ?p ?o ?g. }
- W2078245510 endingPage "438" @default.
- W2078245510 startingPage "429" @default.
- W2078245510 abstract "Abstract Galanin actions are mediated by distinct galanin receptors (GAL-R), GAL-R1, -R2 and -R3. We investigated the role of GAL-R1 in gastric motility and the expression of GAL-R1 in the rat stomach. In vivo, in urethane-anaesthetized rats, galanin (equipotent for all GAL-Rs) induced a short inhibition of gastric motility, followed by increase in tonic and phasic gastric motility; the latter was significantly reduced by the GAL-R1 antagonist, RWJ-57408. Galanin 1–16 (high affinity for GAL-R1 and -R2) induced a long-lasting decrease of intragastric pressure, which was not modified by RWJ-57408. In vitro, galanin and galanin 1–16 induced increase of intragastric pressure that was not affected by RWJ-57408. Tetrodotoxin (TTX) did not suppress the galanin excitatory effect, whereas the effect of galanin 1–16 on gastric contraction was increased by TTX- or N-nitro-L-arginine, an inhibitor of nitric oxide synthase. GAL–R1 immunoreactivity was localized to cholinergic and tachykinergic neurons and to neurons immunoreactive for nitric oxide synthase or vasoactive intestinal polypeptide. This study suggests that an extrinsic GAL-R1 pathway mediates the galanin excitatory action, whereas an extrinsic, non GAL-R1 pathway is likely to mediate the galanin inhibitory effect in vivo. GAL-R1 intrinsic neurons do not appear to play a major role in the control of gastric motility." @default.
- W2078245510 created "2016-06-24" @default.
- W2078245510 creator A5020224282 @default.
- W2078245510 creator A5035114986 @default.
- W2078245510 creator A5040185216 @default.
- W2078245510 creator A5050070079 @default.
- W2078245510 creator A5051345904 @default.
- W2078245510 creator A5058889371 @default.
- W2078245510 creator A5072943433 @default.
- W2078245510 creator A5078834398 @default.
- W2078245510 date "2004-08-01" @default.
- W2078245510 modified "2023-09-27" @default.
- W2078245510 title "Role of galanin receptor 1 in gastric motility in rat" @default.
- W2078245510 cites W1821698232 @default.
- W2078245510 cites W1899254857 @default.
- W2078245510 cites W1963614959 @default.
- W2078245510 cites W1965040939 @default.
- W2078245510 cites W1965578455 @default.
- W2078245510 cites W1967616884 @default.
- W2078245510 cites W1968788780 @default.
- W2078245510 cites W1972499468 @default.
- W2078245510 cites W1972976241 @default.
- W2078245510 cites W1975052684 @default.
- W2078245510 cites W1977450081 @default.
- W2078245510 cites W1981329238 @default.
- W2078245510 cites W1986608344 @default.
- W2078245510 cites W1987542575 @default.
- W2078245510 cites W1991192535 @default.
- W2078245510 cites W2001607934 @default.
- W2078245510 cites W2003767728 @default.
- W2078245510 cites W2004465233 @default.
- W2078245510 cites W2014086167 @default.
- W2078245510 cites W2017759876 @default.
- W2078245510 cites W2026217651 @default.
- W2078245510 cites W2030059572 @default.
- W2078245510 cites W2030195234 @default.
- W2078245510 cites W2033336937 @default.
- W2078245510 cites W2037260170 @default.
- W2078245510 cites W2041895165 @default.
- W2078245510 cites W2045492751 @default.
- W2078245510 cites W2055864783 @default.
- W2078245510 cites W2060552805 @default.
- W2078245510 cites W2063526911 @default.
- W2078245510 cites W2069236530 @default.
- W2078245510 cites W2071254114 @default.
- W2078245510 cites W2074901828 @default.
- W2078245510 cites W2075896270 @default.
- W2078245510 cites W2086669245 @default.
- W2078245510 cites W2089350256 @default.
- W2078245510 cites W2094338128 @default.
- W2078245510 cites W2100720542 @default.
- W2078245510 cites W2121981412 @default.
- W2078245510 cites W2128220751 @default.
- W2078245510 cites W4233086458 @default.
- W2078245510 doi "https://doi.org/10.1111/j.1365-2982.2004.00534.x" @default.
- W2078245510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15305998" @default.
- W2078245510 hasPublicationYear "2004" @default.
- W2078245510 type Work @default.
- W2078245510 sameAs 2078245510 @default.
- W2078245510 citedByCount "10" @default.
- W2078245510 countsByYear W20782455102012 @default.
- W2078245510 countsByYear W20782455102016 @default.
- W2078245510 countsByYear W20782455102019 @default.
- W2078245510 countsByYear W20782455102020 @default.
- W2078245510 countsByYear W20782455102021 @default.
- W2078245510 crossrefType "journal-article" @default.
- W2078245510 hasAuthorship W2078245510A5020224282 @default.
- W2078245510 hasAuthorship W2078245510A5035114986 @default.
- W2078245510 hasAuthorship W2078245510A5040185216 @default.
- W2078245510 hasAuthorship W2078245510A5050070079 @default.
- W2078245510 hasAuthorship W2078245510A5051345904 @default.
- W2078245510 hasAuthorship W2078245510A5058889371 @default.
- W2078245510 hasAuthorship W2078245510A5072943433 @default.
- W2078245510 hasAuthorship W2078245510A5078834398 @default.
- W2078245510 hasConcept C112592302 @default.
- W2078245510 hasConcept C118303440 @default.
- W2078245510 hasConcept C126322002 @default.
- W2078245510 hasConcept C134018914 @default.
- W2078245510 hasConcept C170493617 @default.
- W2078245510 hasConcept C17077164 @default.
- W2078245510 hasConcept C185592680 @default.
- W2078245510 hasConcept C19519825 @default.
- W2078245510 hasConcept C2776741303 @default.
- W2078245510 hasConcept C2777622882 @default.
- W2078245510 hasConcept C36076068 @default.
- W2078245510 hasConcept C519581460 @default.
- W2078245510 hasConcept C58207958 @default.
- W2078245510 hasConcept C71924100 @default.
- W2078245510 hasConcept C8330315 @default.
- W2078245510 hasConcept C86803240 @default.
- W2078245510 hasConcept C95444343 @default.
- W2078245510 hasConceptScore W2078245510C112592302 @default.
- W2078245510 hasConceptScore W2078245510C118303440 @default.
- W2078245510 hasConceptScore W2078245510C126322002 @default.
- W2078245510 hasConceptScore W2078245510C134018914 @default.
- W2078245510 hasConceptScore W2078245510C170493617 @default.
- W2078245510 hasConceptScore W2078245510C17077164 @default.
- W2078245510 hasConceptScore W2078245510C185592680 @default.