FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078249356> ?p ?o ?g. }

• W2078249356 endingPage "759" @default.
• W2078249356 startingPage "750" @default.
• W2078249356 abstract "Surfactant protein D (SP-D)-deficient (SP-D^−/−) mice exhibit early development of emphysema. Previously we have shown that SP-D deficiency results in increased production and activity of inducible NO synthase (iNOS). In this study, we examined whether treatment with the iNOS inhibitor 1400W could inhibit the inflammatory phenotype. Mice were treated with 1400W systemically for 7 wk from 3 wk of age. Treatment reduced total lung NO synthase activity to 14.7 ± 6.1% of saline-treated 10-wk-old SP-D^−/− littermates. Long-term administration of 1400W reduced lung inflammation and cellular infiltration; and significantly attenuated the increased levels of matrix metalloproteinases 2 and 9, chemokines (KC, TARC), and cytokines (IFN-γ) seen in bronchoalveolar lavage (BAL) of SP-D^−/− mice. Abrogation of these levels was associated with decreasing BAL chemotactic activity for RAW cells. Two weeks of treatment with 1400W reduced total lung NO synthase (NOS) activity to 12.7 ± 6.3% of saline-treated SP-D^−/− mice. Short-term iNOS inhibition resulted in attenuation of pulmonary inflammation within SP-D^−/− mice as shown by decreases in total BAL cell count (63 ± 6% of SP-D^−/− control), macrophage size (>25 μm) within the BAL (62 ± 10% of SP-D^−/− control), and a percentage of BAL macrophages producing oxidants (76 ± 9% of SP-D^−/− control). These studies showed that s.c. delivery of 1400W can be achieved in vivo and can attenuate the inflammatory processes within SP-D deficiency. Our results represent the first report linking defects in the innate immune system in the lung with alterations in NO homeostasis." @default.
• W2078249356 created "2016-06-24" @default.
• W2078249356 creator A5040547960 @default.
• W2078249356 creator A5071902446 @default.
• W2078249356 creator A5091536218 @default.
• W2078249356 date "1973-10-01" @default.
• W2078249356 modified "2023-10-16" @default.
• W2078249356 title "Clinical, light, and electron microscopy findings in idiopathic haematuria" @default.
• W2078249356 cites W150439624 @default.
• W2078249356 cites W1548031224 @default.
• W2078249356 cites W186935747 @default.
• W2078249356 cites W1966468710 @default.
• W2078249356 cites W1985114928 @default.
• W2078249356 cites W2018844803 @default.
• W2078249356 cites W2031857572 @default.
• W2078249356 cites W2044369795 @default.
• W2078249356 cites W2051939016 @default.
• W2078249356 cites W2057998049 @default.
• W2078249356 cites W2075831994 @default.
• W2078249356 cites W2083077706 @default.
• W2078249356 cites W2091720479 @default.
• W2078249356 cites W2109297796 @default.
• W2078249356 cites W2333457610 @default.
• W2078249356 cites W2338581977 @default.
• W2078249356 cites W2340365130 @default.
• W2078249356 cites W2377584094 @default.
• W2078249356 cites W2398516331 @default.
• W2078249356 cites W2412751978 @default.
• W2078249356 cites W2419648196 @default.
• W2078249356 cites W2463421699 @default.
• W2078249356 cites W4301445562 @default.
• W2078249356 doi "https://doi.org/10.1136/jcp.26.10.750" @default.
• W2078249356 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/477876" @default.
• W2078249356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4750456" @default.
• W2078249356 hasPublicationYear "1973" @default.
• W2078249356 type Work @default.
• W2078249356 sameAs 2078249356 @default.
• W2078249356 citedByCount "8" @default.
• W2078249356 crossrefType "journal-article" @default.
• W2078249356 hasAuthorship W2078249356A5040547960 @default.
• W2078249356 hasAuthorship W2078249356A5071902446 @default.
• W2078249356 hasAuthorship W2078249356A5091536218 @default.
• W2078249356 hasBestOaLocation W20782493561 @default.
• W2078249356 hasConcept C126322002 @default.
• W2078249356 hasConcept C13373296 @default.
• W2078249356 hasConcept C134018914 @default.
• W2078249356 hasConcept C142724271 @default.
• W2078249356 hasConcept C153911025 @default.
• W2078249356 hasConcept C181199279 @default.
• W2078249356 hasConcept C185592680 @default.
• W2078249356 hasConcept C203014093 @default.
• W2078249356 hasConcept C2776914184 @default.
• W2078249356 hasConcept C2777397205 @default.
• W2078249356 hasConcept C2777622882 @default.
• W2078249356 hasConcept C2777714996 @default.
• W2078249356 hasConcept C2777961210 @default.
• W2078249356 hasConcept C55493867 @default.
• W2078249356 hasConcept C71924100 @default.
• W2078249356 hasConcept C86803240 @default.
• W2078249356 hasConceptScore W2078249356C126322002 @default.
• W2078249356 hasConceptScore W2078249356C13373296 @default.
• W2078249356 hasConceptScore W2078249356C134018914 @default.
• W2078249356 hasConceptScore W2078249356C142724271 @default.
• W2078249356 hasConceptScore W2078249356C153911025 @default.
• W2078249356 hasConceptScore W2078249356C181199279 @default.
• W2078249356 hasConceptScore W2078249356C185592680 @default.
• W2078249356 hasConceptScore W2078249356C203014093 @default.
• W2078249356 hasConceptScore W2078249356C2776914184 @default.
• W2078249356 hasConceptScore W2078249356C2777397205 @default.
• W2078249356 hasConceptScore W2078249356C2777622882 @default.
• W2078249356 hasConceptScore W2078249356C2777714996 @default.
• W2078249356 hasConceptScore W2078249356C2777961210 @default.
• W2078249356 hasConceptScore W2078249356C55493867 @default.
• W2078249356 hasConceptScore W2078249356C71924100 @default.
• W2078249356 hasConceptScore W2078249356C86803240 @default.
• W2078249356 hasIssue "10" @default.
• W2078249356 hasLocation W20782493561 @default.
• W2078249356 hasLocation W20782493562 @default.
• W2078249356 hasLocation W20782493563 @default.
• W2078249356 hasLocation W20782493564 @default.
• W2078249356 hasOpenAccess W2078249356 @default.
• W2078249356 hasPrimaryLocation W20782493561 @default.
• W2078249356 hasRelatedWork W2008087125 @default.
• W2078249356 hasRelatedWork W2009877402 @default.
• W2078249356 hasRelatedWork W2014432291 @default.
• W2078249356 hasRelatedWork W2054119993 @default.
• W2078249356 hasRelatedWork W2056503472 @default.
• W2078249356 hasRelatedWork W2071934027 @default.
• W2078249356 hasRelatedWork W2089295326 @default.
• W2078249356 hasRelatedWork W2093911704 @default.
• W2078249356 hasRelatedWork W2369056050 @default.
• W2078249356 hasRelatedWork W2341096078 @default.
• W2078249356 hasVolume "26" @default.
• W2078249356 isParatext "false" @default.
• W2078249356 isRetracted "false" @default.
• W2078249356 magId "2078249356" @default.
• W2078249356 workType "article" @default.