FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078251012> ?p ?o ?g. }

• W2078251012 endingPage "10" @default.
• W2078251012 startingPage "1" @default.
• W2078251012 abstract "This study aimed to assess the potential anti-angiogenic mechanism of Phyllanthus urinaria (P. urinaria) and characterize the major compound in P. urinaria that exerts anti-angiogenic effect. The water extract of P. urinaria and Ellagic Acid were used to evaluate the anti-angiogenic effect in chorioallantoic membrane (CAM) in chicken embryo and human vascular endothelial cells (HUVECs). The matrix metalloproteinase-2 (MMP-2) activity was determined by gelatin zymography. The mRNA expressions of MMP-2, MMP-14 and tissue inhibitor of metalloproteinase-2 (TIMP-2) were analyzed by reverse transcription polymerase chain reaction (RT-PCR). Level of MMP-2 proteins in conditioned medium or cytosol was determined by western blot analysis. We confirmed that P. urinaria's in vivo anti-angiogenic effect was associated with a reduction in MMP-2 activity. Ellagic acid, one of the major polyphenolic components as identified in P. urinaria by high performance liquid chromatography mass spectrometry (HPLC/MS), exhibited the same anti-angiogenic effect in vivo. Both P. urinaria and Ellagic Acid inhibited MMP-2 activity in HUVECs with unchanged mRNA level. The mRNA expression levels of MMP-14 and TIMP-2 were not altered either. Results from comparing the change of MMP-2 protein levels in conditioned medium and cytosol of HUVECs after the P. urinaria or Ellagic Acid treatment revealed an inhibitory effect on the secretion of MMP-2 protein. This study concluded that Ellagic Acid is the active compound in P. urinaria to exhibit anti-angiogenic activity and to inhibit the secretion of MMP-2 protein from HUVECs." @default.
• W2078251012 created "2016-06-24" @default.
• W2078251012 creator A5000085395 @default.
• W2078251012 creator A5001930884 @default.
• W2078251012 creator A5019128485 @default.
• W2078251012 creator A5042866937 @default.
• W2078251012 creator A5050993542 @default.
• W2078251012 creator A5052810112 @default.
• W2078251012 creator A5080345807 @default.
• W2078251012 date "2011-01-01" @default.
• W2078251012 modified "2023-10-12" @default.
• W2078251012 title "Ellagic Acid, the Active Compound of<i>Phyllanthus urinaria</i>, Exerts<i>In Vivo</i>Anti-Angiogenic Effect and Inhibits MMP-2 Activity" @default.
• W2078251012 cites W1514606825 @default.
• W2078251012 cites W1573363574 @default.
• W2078251012 cites W1969101538 @default.
• W2078251012 cites W1971474452 @default.
• W2078251012 cites W1976838311 @default.
• W2078251012 cites W1985804036 @default.
• W2078251012 cites W1993272437 @default.
• W2078251012 cites W1997387381 @default.
• W2078251012 cites W2002933387 @default.
• W2078251012 cites W2028147914 @default.
• W2078251012 cites W2029773366 @default.
• W2078251012 cites W2037007921 @default.
• W2078251012 cites W2054051579 @default.
• W2078251012 cites W2054374072 @default.
• W2078251012 cites W2057413658 @default.
• W2078251012 cites W2061710186 @default.
• W2078251012 cites W2071318550 @default.
• W2078251012 cites W2073847756 @default.
• W2078251012 cites W2079831464 @default.
• W2078251012 cites W2081395575 @default.
• W2078251012 cites W2088785550 @default.
• W2078251012 cites W2089260591 @default.
• W2078251012 cites W2091309341 @default.
• W2078251012 cites W2108006450 @default.
• W2078251012 cites W2138150045 @default.
• W2078251012 cites W2141592196 @default.
• W2078251012 cites W2149408776 @default.
• W2078251012 cites W2152485827 @default.
• W2078251012 cites W2161163254 @default.
• W2078251012 cites W2327395498 @default.
• W2078251012 cites W4231361699 @default.
• W2078251012 doi "https://doi.org/10.1093/ecam/nep207" @default.
• W2078251012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3095481" @default.
• W2078251012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20007260" @default.
• W2078251012 hasPublicationYear "2011" @default.
• W2078251012 type Work @default.
• W2078251012 sameAs 2078251012 @default.
• W2078251012 citedByCount "35" @default.
• W2078251012 countsByYear W20782510122012 @default.
• W2078251012 countsByYear W20782510122013 @default.
• W2078251012 countsByYear W20782510122014 @default.
• W2078251012 countsByYear W20782510122016 @default.
• W2078251012 countsByYear W20782510122017 @default.
• W2078251012 countsByYear W20782510122018 @default.
• W2078251012 countsByYear W20782510122021 @default.
• W2078251012 countsByYear W20782510122022 @default.
• W2078251012 countsByYear W20782510122023 @default.
• W2078251012 crossrefType "journal-article" @default.
• W2078251012 hasAuthorship W2078251012A5000085395 @default.
• W2078251012 hasAuthorship W2078251012A5001930884 @default.
• W2078251012 hasAuthorship W2078251012A5019128485 @default.
• W2078251012 hasAuthorship W2078251012A5042866937 @default.
• W2078251012 hasAuthorship W2078251012A5050993542 @default.
• W2078251012 hasAuthorship W2078251012A5052810112 @default.
• W2078251012 hasAuthorship W2078251012A5080345807 @default.
• W2078251012 hasBestOaLocation W20782510121 @default.
• W2078251012 hasConcept C104317684 @default.
• W2078251012 hasConcept C109523444 @default.
• W2078251012 hasConcept C150903083 @default.
• W2078251012 hasConcept C185592680 @default.
• W2078251012 hasConcept C202751555 @default.
• W2078251012 hasConcept C207001950 @default.
• W2078251012 hasConcept C2776415932 @default.
• W2078251012 hasConcept C2778004101 @default.
• W2078251012 hasConcept C2780394083 @default.
• W2078251012 hasConcept C2781464872 @default.
• W2078251012 hasConcept C502942594 @default.
• W2078251012 hasConcept C55493867 @default.
• W2078251012 hasConcept C70899900 @default.
• W2078251012 hasConcept C86803240 @default.
• W2078251012 hasConcept C97230052 @default.
• W2078251012 hasConcept C98274493 @default.
• W2078251012 hasConceptScore W2078251012C104317684 @default.
• W2078251012 hasConceptScore W2078251012C109523444 @default.
• W2078251012 hasConceptScore W2078251012C150903083 @default.
• W2078251012 hasConceptScore W2078251012C185592680 @default.
• W2078251012 hasConceptScore W2078251012C202751555 @default.
• W2078251012 hasConceptScore W2078251012C207001950 @default.
• W2078251012 hasConceptScore W2078251012C2776415932 @default.
• W2078251012 hasConceptScore W2078251012C2778004101 @default.
• W2078251012 hasConceptScore W2078251012C2780394083 @default.
• W2078251012 hasConceptScore W2078251012C2781464872 @default.
• W2078251012 hasConceptScore W2078251012C502942594 @default.
• W2078251012 hasConceptScore W2078251012C55493867 @default.
• W2078251012 hasConceptScore W2078251012C70899900 @default.
• W2078251012 hasConceptScore W2078251012C86803240 @default.

• next