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• W2078251508 abstract "Health-care systems are currently being scrutinized and reorganized as they try simultaneously to improve quality of patient care and reduce prices. The prescribing of antimicrobials is an important target for those attempting to achieve this goal, particularly as antibiotics account for between 3 and 25% of all prescriptions, 1 and up to 50% of the drug budget in hospitals. 2 A significant proportion of these drugs costs is due to use of expensive broad-spectrum parenteral agents, often inappropriately prescribed. Indeed, up to 65% of parenteral therapy has been judged inappropriate in some respects. 3,4 This has been the stimulus for policy makers, pharmacists and clinicians to rationalize the prescribing of these agents. However, as opposed to concentrating purely on cost minimization, for example through formulary or restricted list prescribing, 5,6 there is greater emphasis on achieving quality and cost-effective health care. One way of managing this, relevant to parenteral antibiotics, is to consider ‘iv-to-oral’ switch or sequential therapy. This particular strategy has been devel" @default.
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• W2078251508 date "1997-04-01" @default.
• W2078251508 modified "2023-10-14" @default.
• W2078251508 title "Sequential antimicrobial therapy--the role of quinolones" @default.
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• W2078251508 doi "https://doi.org/10.1093/jac/39.4.441" @default.
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