FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078256717> ?p ?o ?g. }

• W2078256717 endingPage "e28615" @default.
• W2078256717 startingPage "e28615" @default.
• W2078256717 abstract "The translocation of synaptic Zn(2+) to the cytosolic compartment has been studied to understand Zn(2+) neurotoxicity in neurological diseases. However, it is unknown whether the moderate increase in Zn(2+) in the cytosolic compartment affects memory processing in the hippocampus. In the present study, the moderate increase in cytosolic Zn(2+) in the hippocampus was induced with clioquinol (CQ), a zinc ionophore. Zn(2+) delivery by Zn-CQ transiently attenuated CA1 long-term potentiation (LTP) in hippocampal slices prepared 2 h after i.p. injection of Zn-CQ into rats, when intracellular Zn(2+) levels was transiently increased in the CA1 pyramidal cell layer, followed by object recognition memory deficit. Object recognition memory was transiently impaired 30 min after injection of ZnCl(2) into the CA1, but not after injection into the dentate gyrus that did not significantly increase intracellular Zn(2+) in the granule cell layer of the dentate gyrus. Object recognition memory deficit may be linked to the preferential increase in Zn(2+) and/or the preferential vulnerability to Zn(2+) in CA1 pyramidal neurons. In the case of the cytosolic increase in endogenous Zn(2+) in the CA1 induced by 100 mM KCl, furthermore, object recognition memory was also transiently impaired, while ameliorated by co-injection of CaEDTA to block the increase in cytosolic Zn(2+). The present study indicates that the transient increase in cytosolic Zn(2+) in CA1 pyramidal neurons reversibly impairs object recognition memory." @default.
• W2078256717 created "2016-06-24" @default.
• W2078256717 creator A5005231141 @default.
• W2078256717 creator A5018612343 @default.
• W2078256717 creator A5023882539 @default.
• W2078256717 creator A5058444251 @default.
• W2078256717 creator A5080347210 @default.
• W2078256717 creator A5087288927 @default.
• W2078256717 creator A5088907249 @default.
• W2078256717 date "2011-12-07" @default.
• W2078256717 modified "2023-10-12" @default.
• W2078256717 title "Transient Increase in Zn2+ in Hippocampal CA1 Pyramidal Neurons Causes Reversible Memory Deficit" @default.
• W2078256717 cites W126551111 @default.
• W2078256717 cites W1524678942 @default.
• W2078256717 cites W1538865085 @default.
• W2078256717 cites W1574937508 @default.
• W2078256717 cites W157666778 @default.
• W2078256717 cites W1963790482 @default.
• W2078256717 cites W1965842048 @default.
• W2078256717 cites W1972992920 @default.
• W2078256717 cites W1974316629 @default.
• W2078256717 cites W1985246582 @default.
• W2078256717 cites W1986503634 @default.
• W2078256717 cites W1988690043 @default.
• W2078256717 cites W1994343347 @default.
• W2078256717 cites W1996934444 @default.
• W2078256717 cites W1997178267 @default.
• W2078256717 cites W2010338437 @default.
• W2078256717 cites W2012122987 @default.
• W2078256717 cites W2014696835 @default.
• W2078256717 cites W2015149991 @default.
• W2078256717 cites W2016496001 @default.
• W2078256717 cites W2016979211 @default.
• W2078256717 cites W2025694378 @default.
• W2078256717 cites W2026257161 @default.
• W2078256717 cites W2030561694 @default.
• W2078256717 cites W2033715624 @default.
• W2078256717 cites W2034669253 @default.
• W2078256717 cites W2037719974 @default.
• W2078256717 cites W2040653138 @default.
• W2078256717 cites W2043903807 @default.
• W2078256717 cites W2045086515 @default.
• W2078256717 cites W2049511526 @default.
• W2078256717 cites W2051650830 @default.
• W2078256717 cites W2054566340 @default.
• W2078256717 cites W2067085911 @default.
• W2078256717 cites W2070990705 @default.
• W2078256717 cites W2071029307 @default.
• W2078256717 cites W2077122729 @default.
• W2078256717 cites W2079793974 @default.
• W2078256717 cites W2092082847 @default.
• W2078256717 cites W2104520607 @default.
• W2078256717 cites W2130606778 @default.
• W2078256717 cites W2131437696 @default.
• W2078256717 cites W2134581713 @default.
• W2078256717 cites W2137288204 @default.
• W2078256717 cites W2138149556 @default.
• W2078256717 cites W2138861499 @default.
• W2078256717 cites W2144730066 @default.
• W2078256717 cites W2149684302 @default.
• W2078256717 cites W2151594784 @default.
• W2078256717 cites W2155347845 @default.
• W2078256717 cites W2160212383 @default.
• W2078256717 cites W2162184782 @default.
• W2078256717 cites W2171749710 @default.
• W2078256717 cites W2410876341 @default.
• W2078256717 doi "https://doi.org/10.1371/journal.pone.0028615" @default.
• W2078256717 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3233599" @default.
• W2078256717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22163318" @default.
• W2078256717 hasPublicationYear "2011" @default.
• W2078256717 type Work @default.
• W2078256717 sameAs 2078256717 @default.
• W2078256717 citedByCount "45" @default.
• W2078256717 countsByYear W20782567172012 @default.
• W2078256717 countsByYear W20782567172013 @default.
• W2078256717 countsByYear W20782567172014 @default.
• W2078256717 countsByYear W20782567172015 @default.
• W2078256717 countsByYear W20782567172016 @default.
• W2078256717 countsByYear W20782567172017 @default.
• W2078256717 countsByYear W20782567172018 @default.
• W2078256717 countsByYear W20782567172019 @default.
• W2078256717 countsByYear W20782567172020 @default.
• W2078256717 countsByYear W20782567172021 @default.
• W2078256717 countsByYear W20782567172022 @default.
• W2078256717 countsByYear W20782567172023 @default.
• W2078256717 crossrefType "journal-article" @default.
• W2078256717 hasAuthorship W2078256717A5005231141 @default.
• W2078256717 hasAuthorship W2078256717A5018612343 @default.
• W2078256717 hasAuthorship W2078256717A5023882539 @default.
• W2078256717 hasAuthorship W2078256717A5058444251 @default.
• W2078256717 hasAuthorship W2078256717A5080347210 @default.
• W2078256717 hasAuthorship W2078256717A5087288927 @default.
• W2078256717 hasAuthorship W2078256717A5088907249 @default.
• W2078256717 hasBestOaLocation W20782567171 @default.
• W2078256717 hasConcept C12554922 @default.
• W2078256717 hasConcept C148762608 @default.
• W2078256717 hasConcept C169760540 @default.
• W2078256717 hasConcept C170493617 @default.

• next