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• W2078258055 abstract "Hair keratin proteins and keratin-associated proteins (KAPs) are the main structural proteins of hair fibers. The specific type I (acidic) and type II (basic/neutral) pairs of hair keratins are assembled into the keratin intermediate filaments in trichocytes [ [1] Steinert P.M. Roop D.R. Molecular and cellular biology of intermediate filaments. Annu Rev Biochem. 1988; 57: 593-625 Crossref PubMed Scopus (1119) Google Scholar ]. The keratin intermediate filaments are embedded in the interfilamentous matrix that is composed of cysteine-rich KAPs functioning as the disulfide bond cross-linking proteins in hair fibers [ [1] Steinert P.M. Roop D.R. Molecular and cellular biology of intermediate filaments. Annu Rev Biochem. 1988; 57: 593-625 Crossref PubMed Scopus (1119) Google Scholar ]. KAP5 subfamily, a member of ultra high sulfur (UHS) KAPs (>30 mol% content), is partially characterized in sheep and human [ [2] MacKinnon P.J. Powell B.C. Rogers G.E. Structure and expression of genes for a class of cysteine-rich proteins of the cuticle layers of differentiating wool and hair follicles. J Cell Biol. 1990; 111: 2587-2600 Crossref PubMed Scopus (74) Google Scholar ]. Although several UHS KAP genes have been predicted both on human chromosome 11 [ [3] MacKinnon P.J. Powell B.C. Rogers G.E. Baker E.G. MacKinnon R.N. Hyland V.J. et al. An ultrahigh-sulphur keratin gene of the human hair cuticle is located at 11q13 and cross-hybridizes with sequences at 11p15. Mamm Genome. 1991; 1: 53-56 Crossref PubMed Scopus (18) Google Scholar ], only two KRN1/KerA (GenBank Accession no. AJ006693 ) and KerB (GenBank Accession no. AJ006692 ) genes as a KAP5 family member were identified on human chromosome 11q13 [ 1 Steinert P.M. Roop D.R. Molecular and cellular biology of intermediate filaments. Annu Rev Biochem. 1988; 57: 593-625 Crossref PubMed Scopus (1119) Google Scholar , 3 MacKinnon P.J. Powell B.C. Rogers G.E. Baker E.G. MacKinnon R.N. Hyland V.J. et al. An ultrahigh-sulphur keratin gene of the human hair cuticle is located at 11q13 and cross-hybridizes with sequences at 11p15. Mamm Genome. 1991; 1: 53-56 Crossref PubMed Scopus (18) Google Scholar , 4 Perez C. Auriol J. Gerst C. Bernard B.A. Egly J.M. Genomic organization and promoter characterization of two human UHS keratin genes. Gene. 1999; 227: 137-148 Crossref PubMed Scopus (11) Google Scholar ]. Recently, nine novel KAP5 members besides KerA and KerB have been eventually mapped on human chromosome 11p15.5 and 11q13.5 [ [5] Yahagi S. Shibuya K. Obayashi I. Masaki H. Kurata Y. Kudoh J. et al. Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11. Biochem Biophys Res Commun. 2004; 318: 655-664 Crossref PubMed Scopus (24) Google Scholar ]. In the report, the expression of all KAP5 genes in hair roots was showed by RT-PCR, but detailed distribution pattern within hair follicles was unexplored. In this study, we compared the expression site of five KAP5 genes on human chromosome 11q13.5 using scalp skin sections." @default.
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• W2078258055 title "Expression of novel keratin associated protein 5 genes in the cuticle layer of human hair follicles" @default.
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• W2078258055 doi "https://doi.org/10.1016/j.jdermsci.2005.02.003" @default.
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