FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078258312> ?p ?o ?g. }

• W2078258312 endingPage "44" @default.
• W2078258312 startingPage "39" @default.
• W2078258312 abstract "Discoidin domain receptor-2 (DDR2) is a cell surface tyrosine kinase receptor that can be activated by soluble collagen and has been implicated in diverse physiological functions including organism growth and wound repair. In the current studies, we used fibronectin and collagen-coated 2D surfaces and collagen matrices in combination with siRNA technology to investigate the role of DDR2 in a range of fibroblast motile activities. Silencing DDR2 with siRNA inhibited cell spreading and migration, and similar inhibition occurred regardless whether cells were interacting with fibronectin or collagen surfaces. Under the assay conditions used, DDR2 tyrosine kinase activation was not observed unless soluble collagen was added to the incubation medium. Finally silencing DDR2 also inhibited human fibroblast migration in 3D collagen matrices but had no effect on 3D collagen matrix remodeling and contraction. Taken together, our findings suggest that DDR2 is required for normal fibroblast spreading and migration independent of adhesion ligand and collagen activation of DDR2 tyrosine kinase." @default.
• W2078258312 created "2016-06-24" @default.
• W2078258312 creator A5038421886 @default.
• W2078258312 creator A5089436132 @default.
• W2078258312 date "2012-12-01" @default.
• W2078258312 modified "2023-10-16" @default.
• W2078258312 title "DDR2 plays a role in fibroblast migration independent of adhesion ligand and collagen activated DDR2 tyrosine kinase" @default.
• W2078258312 cites W1928836998 @default.
• W2078258312 cites W1969375564 @default.
• W2078258312 cites W1969430572 @default.
• W2078258312 cites W1971979173 @default.
• W2078258312 cites W1972747383 @default.
• W2078258312 cites W1989532668 @default.
• W2078258312 cites W1993068443 @default.
• W2078258312 cites W2002502497 @default.
• W2078258312 cites W2013197522 @default.
• W2078258312 cites W2021705436 @default.
• W2078258312 cites W2032318266 @default.
• W2078258312 cites W2040479916 @default.
• W2078258312 cites W2045681515 @default.
• W2078258312 cites W2059253566 @default.
• W2078258312 cites W2074225734 @default.
• W2078258312 cites W2082638158 @default.
• W2078258312 cites W2093784914 @default.
• W2078258312 cites W2100711232 @default.
• W2078258312 cites W2101083650 @default.
• W2078258312 cites W2103048323 @default.
• W2078258312 cites W2118941667 @default.
• W2078258312 cites W2131797874 @default.
• W2078258312 cites W2135533466 @default.
• W2078258312 cites W2136368542 @default.
• W2078258312 cites W2144918562 @default.
• W2078258312 cites W2147000598 @default.
• W2078258312 cites W2151878020 @default.
• W2078258312 cites W2153595347 @default.
• W2078258312 cites W2164490839 @default.
• W2078258312 cites W2166815562 @default.
• W2078258312 cites W2171179595 @default.
• W2078258312 doi "https://doi.org/10.1016/j.bbrc.2012.10.103" @default.
• W2078258312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23131558" @default.
• W2078258312 hasPublicationYear "2012" @default.
• W2078258312 type Work @default.
• W2078258312 sameAs 2078258312 @default.
• W2078258312 citedByCount "14" @default.
• W2078258312 countsByYear W20782583122014 @default.
• W2078258312 countsByYear W20782583122015 @default.
• W2078258312 countsByYear W20782583122016 @default.
• W2078258312 countsByYear W20782583122017 @default.
• W2078258312 countsByYear W20782583122018 @default.
• W2078258312 countsByYear W20782583122019 @default.
• W2078258312 countsByYear W20782583122021 @default.
• W2078258312 countsByYear W20782583122022 @default.
• W2078258312 countsByYear W20782583122023 @default.
• W2078258312 crossrefType "journal-article" @default.
• W2078258312 hasAuthorship W2078258312A5038421886 @default.
• W2078258312 hasAuthorship W2078258312A5089436132 @default.
• W2078258312 hasConcept C101544691 @default.
• W2078258312 hasConcept C119524353 @default.
• W2078258312 hasConcept C1491633281 @default.
• W2078258312 hasConcept C151166631 @default.
• W2078258312 hasConcept C153911025 @default.
• W2078258312 hasConcept C185592680 @default.
• W2078258312 hasConcept C189165786 @default.
• W2078258312 hasConcept C202751555 @default.
• W2078258312 hasConcept C2776305115 @default.
• W2078258312 hasConcept C2780381497 @default.
• W2078258312 hasConcept C42362537 @default.
• W2078258312 hasConcept C55493867 @default.
• W2078258312 hasConcept C62478195 @default.
• W2078258312 hasConcept C85789140 @default.
• W2078258312 hasConcept C86492073 @default.
• W2078258312 hasConcept C86803240 @default.
• W2078258312 hasConcept C95444343 @default.
• W2078258312 hasConceptScore W2078258312C101544691 @default.
• W2078258312 hasConceptScore W2078258312C119524353 @default.
• W2078258312 hasConceptScore W2078258312C1491633281 @default.
• W2078258312 hasConceptScore W2078258312C151166631 @default.
• W2078258312 hasConceptScore W2078258312C153911025 @default.
• W2078258312 hasConceptScore W2078258312C185592680 @default.
• W2078258312 hasConceptScore W2078258312C189165786 @default.
• W2078258312 hasConceptScore W2078258312C202751555 @default.
• W2078258312 hasConceptScore W2078258312C2776305115 @default.
• W2078258312 hasConceptScore W2078258312C2780381497 @default.
• W2078258312 hasConceptScore W2078258312C42362537 @default.
• W2078258312 hasConceptScore W2078258312C55493867 @default.
• W2078258312 hasConceptScore W2078258312C62478195 @default.
• W2078258312 hasConceptScore W2078258312C85789140 @default.
• W2078258312 hasConceptScore W2078258312C86492073 @default.
• W2078258312 hasConceptScore W2078258312C86803240 @default.
• W2078258312 hasConceptScore W2078258312C95444343 @default.
• W2078258312 hasIssue "1-2" @default.
• W2078258312 hasLocation W20782583121 @default.
• W2078258312 hasLocation W20782583122 @default.
• W2078258312 hasOpenAccess W2078258312 @default.
• W2078258312 hasPrimaryLocation W20782583121 @default.
• W2078258312 hasRelatedWork W1993602817 @default.
• W2078258312 hasRelatedWork W2022334495 @default.
• W2078258312 hasRelatedWork W2051493982 @default.

• next