Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078259863> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2078259863 endingPage "A92" @default.
- W2078259863 startingPage "A92.2" @default.
- W2078259863 abstract "<h3>Background and objectives</h3> Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by an acquired IL-2 deficiency, which leads to a homeostatic imbalance between regulatory T cells (Treg) and effector T cells. Recently, the authors have shown that compensation of the IL-2 deficiency in diseased lupus mice by treatment with recombinant IL-2 (IL-2) ameliorates already established disease by promoting the homeostatic proliferation of regulatory T cell (Treg) in the lymphoid organs.1 The aim of this study was to investigate the impact of IL-2 therapy on intrarenal Foxp3+Treg and kidney infiltrating CD4+T cells in (NZBxNZW) F1 mouse model of lupus nephritis. <h3>Materials and methods</h3> (NZBxNZW) F1 mice with active nephritis were treated with recombinant IL-2 either over a short period of 24 h or over a long period of 20 days with PBS as control. Absolute numbers, phenotype and proliferation of kidney infiltrating CD4+T cells were determined by flow cytometry. Cellular infiltrates were also visualised by immunohistochemistry. <h3>Results</h3> Short term IL-2 treated (NZBxNZW) F1 mice resulted in an increase in numbers and frequency of CD4+Foxp3+Treg and strongly enhanced the proliferation of Foxp3+Treg compared to PBS treated control mice. In contrast, the long term IL-2 treatment over a period of 20 days did not result in a persistent expansion of the intrarenal Foxp3+Treg population. However, total numbers of kidney infiltrating CD4+Tcon were reduced in long term treated mice. In addition these CD4+Tcon showed reduced signs of cellular activation. <h3>Conclusions</h3> In this study, the authors found that short term IL-2 treatment is capable to expand the size of the intrarenal Treg pool. On the other hand, long term IL-2 treatment diminishes the numbers of kidney infiltrating CD4+Tcon. These findings underline the important role of intrarenal Treg for the suppression of kidney disease in lupus mice and may in part explain the delay of disease progression induced by treatment with IL-2. Furthermore, these data provide additional rationales for an IL-2 based immunotherapy of human disease." @default.
- W2078259863 created "2016-06-24" @default.
- W2078259863 creator A5017467815 @default.
- W2078259863 creator A5028098701 @default.
- W2078259863 creator A5040568060 @default.
- W2078259863 creator A5059976548 @default.
- W2078259863 creator A5069720053 @default.
- W2078259863 date "2012-02-01" @default.
- W2078259863 modified "2023-10-01" @default.
- W2078259863 title "IL-2 therapy expands intrarenal FOXP3+ regulatory T cells and decreases the number of infiltrating CD4+T cell in murine lupus nephritis" @default.
- W2078259863 cites W2121900746 @default.
- W2078259863 doi "https://doi.org/10.1136/annrheumdis-2011-201239.17" @default.
- W2078259863 hasPublicationYear "2012" @default.
- W2078259863 type Work @default.
- W2078259863 sameAs 2078259863 @default.
- W2078259863 citedByCount "1" @default.
- W2078259863 countsByYear W20782598632020 @default.
- W2078259863 crossrefType "journal-article" @default.
- W2078259863 hasAuthorship W2078259863A5017467815 @default.
- W2078259863 hasAuthorship W2078259863A5028098701 @default.
- W2078259863 hasAuthorship W2078259863A5040568060 @default.
- W2078259863 hasAuthorship W2078259863A5059976548 @default.
- W2078259863 hasAuthorship W2078259863A5069720053 @default.
- W2078259863 hasBestOaLocation W20782598631 @default.
- W2078259863 hasConcept C126322002 @default.
- W2078259863 hasConcept C203014093 @default.
- W2078259863 hasConcept C2776090121 @default.
- W2078259863 hasConcept C2776912625 @default.
- W2078259863 hasConcept C2778296632 @default.
- W2078259863 hasConcept C2779134260 @default.
- W2078259863 hasConcept C2779727006 @default.
- W2078259863 hasConcept C2779912601 @default.
- W2078259863 hasConcept C2908647359 @default.
- W2078259863 hasConcept C553184892 @default.
- W2078259863 hasConcept C71924100 @default.
- W2078259863 hasConcept C79484868 @default.
- W2078259863 hasConcept C8891405 @default.
- W2078259863 hasConcept C99454951 @default.
- W2078259863 hasConceptScore W2078259863C126322002 @default.
- W2078259863 hasConceptScore W2078259863C203014093 @default.
- W2078259863 hasConceptScore W2078259863C2776090121 @default.
- W2078259863 hasConceptScore W2078259863C2776912625 @default.
- W2078259863 hasConceptScore W2078259863C2778296632 @default.
- W2078259863 hasConceptScore W2078259863C2779134260 @default.
- W2078259863 hasConceptScore W2078259863C2779727006 @default.
- W2078259863 hasConceptScore W2078259863C2779912601 @default.
- W2078259863 hasConceptScore W2078259863C2908647359 @default.
- W2078259863 hasConceptScore W2078259863C553184892 @default.
- W2078259863 hasConceptScore W2078259863C71924100 @default.
- W2078259863 hasConceptScore W2078259863C79484868 @default.
- W2078259863 hasConceptScore W2078259863C8891405 @default.
- W2078259863 hasConceptScore W2078259863C99454951 @default.
- W2078259863 hasIssue "Suppl 1" @default.
- W2078259863 hasLocation W20782598631 @default.
- W2078259863 hasOpenAccess W2078259863 @default.
- W2078259863 hasPrimaryLocation W20782598631 @default.
- W2078259863 hasRelatedWork W1510545292 @default.
- W2078259863 hasRelatedWork W2034441290 @default.
- W2078259863 hasRelatedWork W2066564034 @default.
- W2078259863 hasRelatedWork W2119314438 @default.
- W2078259863 hasRelatedWork W2352803447 @default.
- W2078259863 hasRelatedWork W2557824768 @default.
- W2078259863 hasRelatedWork W2596082138 @default.
- W2078259863 hasRelatedWork W2798146318 @default.
- W2078259863 hasRelatedWork W2978025240 @default.
- W2078259863 hasRelatedWork W4280517121 @default.
- W2078259863 hasVolume "71" @default.
- W2078259863 isParatext "false" @default.
- W2078259863 isRetracted "false" @default.
- W2078259863 magId "2078259863" @default.
- W2078259863 workType "article" @default.