Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078260061> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2078260061 endingPage "122" @default.
- W2078260061 startingPage "109" @default.
- W2078260061 abstract "2,2'-Dichlorodiethyl sulfide (sulfur mustard, HD) extensively alkylates DNA in a concentration-dependent manner in many cell types. We have proposed a biochemical hypothesis that explains HD-induced injury by linking DNA alkylation and DNA breaks with activation of poly(ADP-ribose) polymerase, resulting in depletion of cellular NAD+. This hypothesis was tested by treating human leukocytes with HD to determine whether NAD+ depletion occurred as predicted. These cells demonstrated a decrease in NAD+ levels which was dependent on both concentration of HD and time after exposure. Inhibitors of poly(ADP-ribose) polymerase or substrates for NAD+ synthesis were able to prevent the HD-induced NAD+ decrease." @default.
- W2078260061 created "2016-06-24" @default.
- W2078260061 creator A5006054318 @default.
- W2078260061 creator A5079121096 @default.
- W2078260061 creator A5087783336 @default.
- W2078260061 date "1987-11-01" @default.
- W2078260061 modified "2023-10-12" @default.
- W2078260061 title "2,2′-Dichlorodiethyl sulfide (sulfur mustard) decreases nad+ levels in human leukocytes" @default.
- W2078260061 cites W1377731 @default.
- W2078260061 cites W1964871000 @default.
- W2078260061 cites W1972962961 @default.
- W2078260061 cites W1991179544 @default.
- W2078260061 cites W2001872459 @default.
- W2078260061 cites W2007004764 @default.
- W2078260061 cites W2007697951 @default.
- W2078260061 cites W2015206944 @default.
- W2078260061 cites W2056071290 @default.
- W2078260061 cites W2059975377 @default.
- W2078260061 cites W2069834296 @default.
- W2078260061 cites W2073276461 @default.
- W2078260061 cites W2078030319 @default.
- W2078260061 cites W2079488878 @default.
- W2078260061 cites W2083392054 @default.
- W2078260061 cites W2119913810 @default.
- W2078260061 cites W2147574940 @default.
- W2078260061 cites W2166309994 @default.
- W2078260061 cites W2325814368 @default.
- W2078260061 cites W4245939282 @default.
- W2078260061 cites W4377077254 @default.
- W2078260061 cites W85996255 @default.
- W2078260061 cites W991841292 @default.
- W2078260061 doi "https://doi.org/10.1016/0378-4274(87)90263-3" @default.
- W2078260061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3672551" @default.
- W2078260061 hasPublicationYear "1987" @default.
- W2078260061 type Work @default.
- W2078260061 sameAs 2078260061 @default.
- W2078260061 citedByCount "82" @default.
- W2078260061 countsByYear W20782600612013 @default.
- W2078260061 countsByYear W20782600612016 @default.
- W2078260061 countsByYear W20782600612017 @default.
- W2078260061 countsByYear W20782600612020 @default.
- W2078260061 crossrefType "journal-article" @default.
- W2078260061 hasAuthorship W2078260061A5006054318 @default.
- W2078260061 hasAuthorship W2078260061A5079121096 @default.
- W2078260061 hasAuthorship W2078260061A5087783336 @default.
- W2078260061 hasConcept C143425029 @default.
- W2078260061 hasConcept C153911025 @default.
- W2078260061 hasConcept C178790620 @default.
- W2078260061 hasConcept C181199279 @default.
- W2078260061 hasConcept C182979987 @default.
- W2078260061 hasConcept C185592680 @default.
- W2078260061 hasConcept C2780596425 @default.
- W2078260061 hasConcept C2780644109 @default.
- W2078260061 hasConcept C29730261 @default.
- W2078260061 hasConcept C45510557 @default.
- W2078260061 hasConcept C518881349 @default.
- W2078260061 hasConcept C552990157 @default.
- W2078260061 hasConcept C55493867 @default.
- W2078260061 hasConcept C75520062 @default.
- W2078260061 hasConcept C82381507 @default.
- W2078260061 hasConcept C86803240 @default.
- W2078260061 hasConceptScore W2078260061C143425029 @default.
- W2078260061 hasConceptScore W2078260061C153911025 @default.
- W2078260061 hasConceptScore W2078260061C178790620 @default.
- W2078260061 hasConceptScore W2078260061C181199279 @default.
- W2078260061 hasConceptScore W2078260061C182979987 @default.
- W2078260061 hasConceptScore W2078260061C185592680 @default.
- W2078260061 hasConceptScore W2078260061C2780596425 @default.
- W2078260061 hasConceptScore W2078260061C2780644109 @default.
- W2078260061 hasConceptScore W2078260061C29730261 @default.
- W2078260061 hasConceptScore W2078260061C45510557 @default.
- W2078260061 hasConceptScore W2078260061C518881349 @default.
- W2078260061 hasConceptScore W2078260061C552990157 @default.
- W2078260061 hasConceptScore W2078260061C55493867 @default.
- W2078260061 hasConceptScore W2078260061C75520062 @default.
- W2078260061 hasConceptScore W2078260061C82381507 @default.
- W2078260061 hasConceptScore W2078260061C86803240 @default.
- W2078260061 hasIssue "1" @default.
- W2078260061 hasLocation W20782600611 @default.
- W2078260061 hasLocation W20782600612 @default.
- W2078260061 hasOpenAccess W2078260061 @default.
- W2078260061 hasPrimaryLocation W20782600611 @default.
- W2078260061 hasRelatedWork W1759444849 @default.
- W2078260061 hasRelatedWork W1966681673 @default.
- W2078260061 hasRelatedWork W2003721498 @default.
- W2078260061 hasRelatedWork W2038234449 @default.
- W2078260061 hasRelatedWork W2056997115 @default.
- W2078260061 hasRelatedWork W2078260061 @default.
- W2078260061 hasRelatedWork W2090245768 @default.
- W2078260061 hasRelatedWork W2140029877 @default.
- W2078260061 hasRelatedWork W3138133458 @default.
- W2078260061 hasRelatedWork W3194717113 @default.
- W2078260061 hasVolume "39" @default.
- W2078260061 isParatext "false" @default.
- W2078260061 isRetracted "false" @default.
- W2078260061 magId "2078260061" @default.
- W2078260061 workType "article" @default.