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• W2078262203 abstract "The transcription factors T-bet and Bcl-6 are required for the establishment of a T helper type 1 cell (T(H)1 cell) and follicular helper T cell (T(FH) cell) gene-expression profile, respectively. Here we found that high concentrations of interleukin 2 (IL-2) inhibited Bcl-6 expression in polarized T(H)1 cells. Mechanistically, the low concentrations of Bcl-6 normally found in effector T(H)1 cells did not repress its target genes because a T-bet-Bcl-6 complex masked the Bcl-6 DNA-binding domain. T(H)1 cells increased their Bcl-6/T-bet ratio in response to limiting IL-2 conditions, which allowed excess Bcl-6 to repress its direct target Prdm1 (which encodes the transcriptional repressor Blimp-1). The Bcl-6-dependent repression of Blimp-1 effectively induced a partial T(FH) profile because Blimp-1 directly repressed a subset of T(FH) signature genes, including Cxcr5. Thus, IL-2-signaling regulates the Bcl-6-Blimp-1 axis in T(H)1 cells to maintain flexibility with a T(FH) cell-like gene profile." @default.
• W2078262203 created "2016-06-24" @default.
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• W2078262203 creator A5081783185 @default.
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• W2078262203 date "2012-03-11" @default.
• W2078262203 modified "2023-10-01" @default.
• W2078262203 title "Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile" @default.
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• W2078262203 doi "https://doi.org/10.1038/ni.2242" @default.
• W2078262203 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3561768" @default.
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• W2078262203 hasPublicationYear "2012" @default.
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