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- W2078263539 abstract "Semen analysis (SA) may provide initial diagnosis of male factor infertility. The reliability of repeated SA producing valuable prognostic information for in vitro fertilization (IVF) success is inconsistent. The risk of failed fertilization is low (∼5%) and the financial and emotional costs of an unsuccessful IVF cycle are significant1. HBA is a sperm function test that provides qualitative assessment of sperm quality, maturity, and fertilization potential by measuring the proportion of sperm bound to hyaluronan. Semen samples with HBA scores of ≤65% are reported to be suboptimal and benefit from in vitro selection of hyaluronan-bound sperm in ICSI2. To determine whether HBA is a better predictor of fertilization success than the current IVF laboratory criteria (total motile normal morphology sperm count >20 million/mL on retrieval day). Retrospective review of all patients meeting the laboratory criteria for conventional insemination and having HBA on both diagnostic (d) and IVF sperm preparation (i) SA at a single fertility center between August 2013-2014. Pearson coefficient was calculated to determine correlation of SA parameters and conventional insemination fertilization rates (FR). 69 patient charts were reviewed with 8 patients having suboptimal FR (11%) including 3 failed and 5 low FR (defined as < 50% of mature oocytes). No correlation was found between dSA HBA score and FR (r= -0.005, 95% CI -0.242-0.232), or between the iSA HBA score and FR (coefficient -0.052, 95% CI -0.285-0.187). All failed fertilization and the majority of patients with low FR (60%) had elevated dHBA and iHBA values. Sperm morphology in dSA and/or iSA were not predictive of FR (r= -0.079, 95% CI -0.312 - 0.162; r= -0.126, 95% CI -0.368-0.133). Total motile count in the dSA and/or iSA were not predictive of FR (r= 0.115, 95% CI -0.125 - 0.343; r= -0.068, 95% CI -0.300-0.171). No correlation could be determined between dHBA or iHBA values. Total motile count, sperm morphology and HBA were not predictive of fertilization success or failure in conventional insemination IVF cycles. In addition, HBA values were not reproducible between SA samples and may not be a more accurate diagnostic sperm function test to predict fertilization potential." @default.
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- W2078263539 date "2015-02-01" @default.
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- W2078263539 title "Semen Parameters as Predictors of Fertilization Success in Conventional Insemination Cases: Is Hyaluronan Binding Assay (HBA) More Sensitive in Normospermic Samples?" @default.
- W2078263539 doi "https://doi.org/10.1016/j.fertnstert.2014.12.057" @default.
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