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- W2078265978 abstract "Abstract Fundamental differences in behavior between synthetic surfactants and taurocholate as a natural model surfactant, relative to their influences on xenobiotic absorption, previously found in rat colon, are now also shown to exist in the small intestine. These differences have been revealed using the absroption-lipophilicity correlation approach, with a homologous phenylalkylcarboxylic acid series. In order to prevent extensive intrinsic absorption of taurocholate, which could mask its true mechanisms of actuation, the proximal half of the rat small intestine was used for absorption tests, after examination of the absorption potentialities of the different small intestinal fractions. The biophysical model describing xenobiotic absorption in the presence of taurocholate at its critical micelle concentration (CMC) does not change relative to that found for xenobiotics in free solution, which are clearly bihyperbolic in nature. At supramicellar concentration (SMC) and in the presence of mixed micelles with lecithin, taurocholate leads to a bilinear correlation for membrane permeation. This means that the effect of the natural surfactant at the CMC on xenobiotic absorption is unimportant, while at the SMC a micelle-solubilizing effect, which is reinforced in the presence of mixed micelles, is evident. On this basis, a general assumption is made to explain the in vivo absorption promoting capacity of bile salts for some lipophilic drugs." @default.
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- W2078265978 title "Compared effects of synthetic and natural bile acid surfactants on xenobiotic absorption: IV. Studies with taurocholate in the rat small intestine" @default.
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- W2078265978 doi "https://doi.org/10.1016/0378-5173(94)90382-4" @default.
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