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- W2078266237 abstract "Eight drimane sesquiterpenes (1−8), six isochromane derivatives (9−14), and three known compounds, daldinin B (15), 9α-hydroxy-6β-[(2E,4E,6E)-octa-2,4,6-trienoyloxy]-5α-drim-7-en-11,12-olide (16), and pergillin (17), were isolated from the EtOAc extract of the marine-derived fungus Aspergillus ustus 094102. The structures of the new compounds were elucidated on the basis of spectroscopic analysis. The cytotoxic effects on A549 and HL-60 cell lines were evaluated by SRB and MTT methods. Ustusorane E (13) showed significant cytotoxicity against HL-60 cells with an IC50 value of 0.13 μM. Ustusolates C (6) and E (8) exhibited moderate cytotoxicity against A549 and HL-60 cells with IC50 values of 10.5 and 9.0 μM, respectively, and ustusolate A (4) showed weak cytotoxicity against HL-60 and A549 cells with IC50 values of 20.6 and 30.0 μM, respectively." @default.
- W2078266237 created "2016-06-24" @default.
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- W2078266237 date "2009-09-21" @default.
- W2078266237 modified "2023-10-17" @default.
- W2078266237 title "Sesquiterpenoids and Benzofuranoids from the Marine-Derived Fungus <i>Aspergillus ustus</i> 094102" @default.
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- W2078266237 doi "https://doi.org/10.1021/np900268z" @default.
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