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- W2078272275 abstract "Radiolabelled derivatives of 1-(2′fluoro-2′-deoxy-β-D-ribofuranosyl)uracil 3 (2′-FUdR) and 1-(2′-chloro-2′-deoxy-β-D-ribofuranosyl)uracil 4 (2′-ClUdR) were synthesized for evaluation as diagnostic radiopharmaceuticals. 6-[3H]-2′-FUdR (21% radiochemical yield from 6-[3H]-uridine; 4.26 GBq mmol−1) and 2-[14C]-2′-FUdR (25% radiochemical yield; 1.85 GBq mmol−1 were prepared by reaction of anhydrous hydrogen fluoride (AHF) with 6-[3H]- or 2-[14C]-labelled 2,2′-anhydro-1-β-D-arabinofuranosyluracil 2 (2,2′-AUR). 6-[3H]-2′-ClUdR (53% radiochemical yield; 11.1 GBq mmol-t-1) was prepared by reaction of CaCl2 with 6-[3H]-2,2′-AUR. Reaction of [18F]-AHF with 2,2′-AUR afforded 2′-[18F]-2′-FUdR in low radiochemical yield while reaction of 2,2′-AUR with [36Cl]-NaCl and trifluoroacetic acid gave 2′-[36Cl]-2′-ClUdR (30% radiochemical yield; 5.46 MBq mmol−1). 2′-[34mCl]-2′-ClUdR was similarly prepared using [34mCl]-MgCl2 or [34mCl]-Dowex 21-K resin in 2.7% (16.8 MBq mmol−1) and 36% (0.304 GBq mmol−1) radiochemical yield respectively." @default.
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- W2078272275 date "1985-03-01" @default.
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- W2078272275 title "The synthesis of radiolabelled 1-(2′-Fluoro-2′-deoxy-β-D-ribofuranosyl)-uracil and 1-(2′-chloro-2′-deoxy-β-D-ribofuranosyl)uracil" @default.
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- W2078272275 doi "https://doi.org/10.1016/0020-708x(85)90074-2" @default.
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