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- W2078273531 abstract "The behavioural effects of physostigmine (0.02–0.10 mg/kg) were studied using the acquisition of a position discrimination in rats. The drug affected performance when administered before the training or test session, but failed to affect performance on the test session when administered before or immediately after the training session. Small doses of physostigmine (0.02 and 0.06 mg/kg) were shown to bring about an improvement in performance, while a larger dose (0·10 mg/kg) was shown to bring about an impairment. The effects of other acetylcholine-related drugs were then studied. The results suggested that the changes in performance brought about by the cholinesterase inhibitor were related to its effects on central cholinergic transmission. It was argued that the results support the hypothesis that cholinergic transmission is involved in mechanisms of response inhibition and that acetylcholine-related drugs do not affect the processes of learning or memory." @default.
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- W2078273531 date "1973-05-01" @default.
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- W2078273531 title "Effects of physostigmine on the acquisition of a position discrimination in rats" @default.
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- W2078273531 doi "https://doi.org/10.1016/0028-3908(73)90064-6" @default.
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