Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078274802> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- W2078274802 abstract "A 35-year-old woman experienced tetanic symptoms when treated with chorionic gonadotrophins or estrogenic oral contraceptives. Persistent hypocalcemia was found, with hyperphosphatemia, normal renal function and low normal plasma parathyroid hormone (PTH), all consistent with idiopathic hypoparathyroidism. During EDTA infusion, no PTH response was measured with a predominantly anti-NH2-terminal antiserum, but a normal response was found with a predominantly anti-COOH-terminal antiserum. This supposes secretion of an immunologically abnormal and biologically ineffective PTH. Oral administration of ethinyl estradiol caused an impressive hypocalcemia with tetanic symptoms. Estrogens might, therefore, inhibit bone resorption by a specific action on bone, and not by antagonizing the action of PTH.Though tetany is not among the reported side effects of oral contraceptive usage, specifically of the use of estrogen, a case study is reported which links the development of tetany to administration of estrogen-containing oral contraceptives. The case was a 35-year-old woman, who presented with muscular cramps and hypocalcemia of unknown origen. 4 years earlier, shortly after taking an oral contraceptive preparation, she had experienced the same symptoms; now, she was reacting apparently to treatment with chorionic gonadotropins for mild obesity. Clinically, she evinced persistent hypocalcemia, hyperphosphatemia, normal renal function, and low plasma parathyroid hormone (PTH); such characteristics are consistent with hypoparathyroidism. With the former, no PTH response was measured, whereas with the latter antiserum, normal response of PTH was found; hence, it was concluded that the patient's PTH was immunologically abnormal and biologically ineffective. These data support the hypothesis that estrogens have a PTH-independent effect on bone; i.e., oral administration of estogens (in this case ethinylestradiol) caused hypocalcemia with tetanic symptoms resulting from estrogenic inhibition of bone resorption by specific action on the bone, not by antagonizing PTH action in vivo." @default.
- W2078274802 created "2016-06-24" @default.
- W2078274802 creator A5011404558 @default.
- W2078274802 creator A5020258465 @default.
- W2078274802 creator A5043586241 @default.
- W2078274802 date "1975-01-01" @default.
- W2078274802 modified "2023-09-24" @default.
- W2078274802 title "Estrogen-Induced Tetany in Idiopathic Hypoparathyroidism" @default.
- W2078274802 doi "https://doi.org/10.1159/000178681" @default.
- W2078274802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/820624" @default.
- W2078274802 hasPublicationYear "1975" @default.
- W2078274802 type Work @default.
- W2078274802 sameAs 2078274802 @default.
- W2078274802 citedByCount "8" @default.
- W2078274802 countsByYear W20782748022014 @default.
- W2078274802 crossrefType "journal-article" @default.
- W2078274802 hasAuthorship W2078274802A5011404558 @default.
- W2078274802 hasAuthorship W2078274802A5020258465 @default.
- W2078274802 hasAuthorship W2078274802A5043586241 @default.
- W2078274802 hasConcept C126322002 @default.
- W2078274802 hasConcept C134018914 @default.
- W2078274802 hasConcept C2775941721 @default.
- W2078274802 hasConcept C2776036575 @default.
- W2078274802 hasConcept C2777043484 @default.
- W2078274802 hasConcept C2777164284 @default.
- W2078274802 hasConcept C2781208988 @default.
- W2078274802 hasConcept C519063684 @default.
- W2078274802 hasConcept C71924100 @default.
- W2078274802 hasConceptScore W2078274802C126322002 @default.
- W2078274802 hasConceptScore W2078274802C134018914 @default.
- W2078274802 hasConceptScore W2078274802C2775941721 @default.
- W2078274802 hasConceptScore W2078274802C2776036575 @default.
- W2078274802 hasConceptScore W2078274802C2777043484 @default.
- W2078274802 hasConceptScore W2078274802C2777164284 @default.
- W2078274802 hasConceptScore W2078274802C2781208988 @default.
- W2078274802 hasConceptScore W2078274802C519063684 @default.
- W2078274802 hasConceptScore W2078274802C71924100 @default.
- W2078274802 hasLocation W20782748021 @default.
- W2078274802 hasLocation W20782748022 @default.
- W2078274802 hasOpenAccess W2078274802 @default.
- W2078274802 hasPrimaryLocation W20782748021 @default.
- W2078274802 hasRelatedWork W1986803862 @default.
- W2078274802 hasRelatedWork W2011773082 @default.
- W2078274802 hasRelatedWork W2032135903 @default.
- W2078274802 hasRelatedWork W2054286114 @default.
- W2078274802 hasRelatedWork W2095529129 @default.
- W2078274802 hasRelatedWork W2107057021 @default.
- W2078274802 hasRelatedWork W2110463251 @default.
- W2078274802 hasRelatedWork W2113024085 @default.
- W2078274802 hasRelatedWork W2162385374 @default.
- W2078274802 hasRelatedWork W1972645091 @default.
- W2078274802 isParatext "false" @default.
- W2078274802 isRetracted "false" @default.
- W2078274802 magId "2078274802" @default.
- W2078274802 workType "article" @default.