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- W2078274931 abstract "Carcinoembryonic antigen cell adhesion molecule like I (CEACAM1) is expressed on activated T cells and signals through either a long (L) cytoplasmic tail containing immune receptor tyrosine based inhibitory motifs, which provide inhibitory function, or a short (S) cytoplasmic tail with an unknown role. Previous studies on peripheral T cells show that CEACAM1-L isoforms predominate with little to no detectable CEACAM1-S isoforms in mouse and human. We show here that this was not the case in tissue resident T cells of intestines and gut associated lymphoid tissues, which demonstrated predominant expression of CEACAM1-S isoforms relative to CEACAM1-L isoforms in human and mouse. This tissue resident predominance of CEACAM1-S expression was determined by the intestinal environment where it served a stimulatory function leading to the regulation of T cell subsets associated with the generation of secretory IgA immunity, the regulation of mucosal commensalism, and defense of the barrier against enteropathogens." @default.
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- W2078274931 date "2012-11-01" @default.
- W2078274931 modified "2023-10-16" @default.
- W2078274931 title "The Short Isoform of the CEACAM1 Receptor in Intestinal T Cells Regulates Mucosal Immunity and Homeostasis via Tfh Cell Induction" @default.
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- W2078274931 doi "https://doi.org/10.1016/j.immuni.2012.07.016" @default.
- W2078274931 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3516394" @default.
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- W2078274931 hasPublicationYear "2012" @default.
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