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• W2078275307 endingPage "1783" @default.
• W2078275307 startingPage "1773" @default.
• W2078275307 abstract "By linking actin dynamics to extracellular components, integrins are involved in a wide range of cellular processes that are associated with or require cytoskeletal remodelling and cell-shape changes. One such function is integrin-dependent phagocytosis, a process that several integrins are capable of mediating and that allows the binding and clearance of particles. Integrin-dependent phagocytosis is involved in a wide range of physiological processes, from the clearance of microorganisms and apoptotic-cell removal to extracellular-matrix remodelling. Integrin signalling is also exploited by microbial pathogens for entry into host cells. Far from being a particular property of specific integrins and specialised cells, integrin-dependent uptake is emerging as a general, intrinsic ability of most integrins that is associated with their capacity to signal to the actin cytoskeleton. Integrin-mediated phagocytosis can therefore be used as a robust model in which to study integrin regulation and signalling." @default.
• W2078275307 created "2016-06-24" @default.
• W2078275307 creator A5032535198 @default.
• W2078275307 creator A5088324031 @default.
• W2078275307 date "2008-06-01" @default.
• W2078275307 modified "2023-10-17" @default.
• W2078275307 title "Integrin-dependent phagocytosis – spreading from microadhesion to new concepts" @default.
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