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• W2078275443 abstract "1 The effects of imidazopyrazine derivative, SCA40, on the activity of single large conductance, Ca2+-activated K+ (BKCa) channels in inside-out and outside-out patches from bovine tracheal smooth muscle (BTSM) cells in culture have been compared with those of two established BKCa channel openers, NS 004 and NS 1619. 2 The presence of BKCa channels on inside-out patches of BTSM membranes was confirmed by the single channel conductance (240 pS), selectivity for K+, dependence of channel activity on [Ca2+], and sensitivity to the selective BKca channel blocker, iberio toxin. 3 NS 004 and ND 1619 (3-30 μM) induced concentration-related increases in open state probability of BKca channels when applied to either inside-out or outside-out BTSM patches, thus confirming that these compounds are activators of the BKCa channel in this preparation. 4 SCA40 (0.1-10 μM) had no effect on the activity of BKCa channels when applied to either inside-out or outside-out patches which subsequently responded to the application of NS 004 (10-20 μM). 5 It is concluded that SCA40 does not have a direct effect on BKca channel activity in BTSM patches and that the previously reported relaxant action of SCA40 on tracheal smooth muscle is unlikely to be mediated by this mechanism." @default.
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• W2078275443 date "1995-09-01" @default.
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• W2078275443 title "A comparison of the effects of SCA40, NS 004 and NS 1619 on large conductance Ca2+-activated K+ channels in bovine tracheal smooth muscle cells in culture" @default.
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• W2078275443 doi "https://doi.org/10.1111/j.1476-5381.1995.tb16387.x" @default.
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